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在重复性扩散创伤性脑损伤小鼠模型中诱导创伤后癫痫

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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

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在重复性扩散创伤性脑损伤小鼠模型中诱导创伤后癫痫

DOI:

10.3791/60360-v

•

07:07 min

•

February 10, 2020

•

Oleksii Shandra, Stefanie Robel^2,3

¹Fralin Biomedical Research Institute at Virginia Tech Carilion, ²School of Neuroscience,Virginia Tech, ³Department of Biological Sciences,Virginia Tech

Capítulos

00:04Título
00:56Weight Drop Traumatic Brain Injury (TBI)
02:01Electroencephalography (EEG) Electrode Implantation Surgical Field Preparation
03:11EEG Electrode Implantation
05:13Results: Representative Spontaneous Seizure Depictions and Timelines
06:17Conclusion

Summary

Tadução automática

此系统协议描述了重复性轻度创伤性脑损伤后创伤后癫痫的新动物模型。第一部分详细介绍了使用修改后的降重模型进行创伤性脑损伤诱导的步骤。第二部分对单通道和多通道脑电图数据采集系统的手术方法进行了说明。

Tags

Keywords: Post-traumatic Epilepsy Mouse Model Traumatic Brain Injury Diffuse Injury Biomarkers Treatments Mild Traumatic Brain Injury Concussion EEG Electrode Implantation Stereotactic Apparatus Periosteum Cranium High-speed Drill

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