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Bone Marrow Transplantation Plattform för att undersöka rollen av dendritiska celler i Graft-versus-Host Disease
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1Cancer Division, Burnett School of Biomedical Sciences,University of Central Florida, 2Department of Biochemistry,Hanoi University of Pharmacy, 3Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences,Houston Methodist Research Institute, 4Department of Epidemiology,University of Pittsburgh Graduate School of Public Health, 5Division of Cancer Control and Population Sciences,University of Pittsburgh Medical Center, Hillman Cancer Center
Capítulos
- 00:04Introduction
- 00:49Graft-Versus-Host Disease (GVHD) Induction
- 02:53Donor T Cell Preparation
- 04:54Bone Marrow-Derived Dendritic Cell (BM-DC) Preparation
- 05:58Results: Representative Effects of Dendritic Cell Function in GVHD
- 07:26Conclusion
Graft-versus-host sjukdom är en stor komplikation efter allogena benmärg transplantation. Dendritiska celler spelar en avgörande roll i patogenesen vid graft-versus-host sjukdom. Den aktuella artikeln beskriver en ny benmärg transplantation plattform för att undersöka dendritiska cellers roll i utvecklingen av graft-versus-host sjukdom och graft-versus-leukemi effekt.
Tags
Keywords: Bone Marrow TransplantationDendritic CellsGraft-versus-host DiseaseT-cell DepletionCell IsolationCell CultureImmune Cell PopulationsMacrophagesNeutrophilsCell RegenerationBone Marrow PreparationCell HarvestingCell StrainingCell WashingCell ResuspensionCell IncubationCell CountingCell Pooling
