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の調製と評価<sup> 99メートル</sup> Tc標識三座キレートバイオ直交化学反応を用いて事前ターゲティングするため
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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
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の調製と評価<sup> 99メートル</sup> Tc標識三座キレートバイオ直交化学反応を用いて事前ターゲティングするため

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10:54 min

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February 04, 2017

DOI:

10.3791/55188-v

DOI:
10.3791/55188-v

•

10:54 min
February 04, 2017

•

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, , , ,
1Department of Chemistry and Chemical Biology,McMaster University

Summary

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Here, we describe a protocol for radiolabeling and in vivo testing of tridentate 99mTc(I) chelate-tetrazine derivatives for pre-targeting and bioorthogonal chemistry.

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99mTc-labeled Tridentate ChelatesPre-targetingBioorthogonal ChemistryTetrazinesTechnetium-99mRadiolabelingMicrowave SynthesisTargeting VectorsRadiopharmaceuticalsDiagnostic ImagingRadiotherapy

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Bilton, H. A., Ahmad, Z., Janzen, N., Czorny, S., Valliant, J. F. Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry. J. Vis. Exp. (120), e55188, doi:10.3791/55188 (2017).

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