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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
 

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Article DOI: 10.3791/54776-v • 11:27 min • December 4th, 2016
December 4th, 2016 •
1, 1, 1, 1
1MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics

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This protocol describes the preparation and characterization of a dendrimeric magnetic resonance imaging (MRI) contrast agent that carries cyclen-based macrocyclic chelates coordinating paramagnetic gadolinium ions. In a series of MRI experiments in vitro, this agent produced an amplified MRI signal when compared to the commercially available monomeric analogue.

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Preparation In Vitro Characterization Dendrimer-based Contrast Agents Magnetic Resonance Imaging MRI Contrast Agents Imaging Experiment Properties Efficacy Convenient Preparation High Protein Easy Characterization Structural Modifications Functional Optimizations In Vivo Applications Biomedical Research Diagnostic Imaging Tissue Retention Times Enhance MRI Signal Macrocyclic Precursor DO3A Tributyl Ester DMF Potassium Carbonate Tert-butyl-2-bromo-4 4-nitrophenyl Butatnoate
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