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利用功能基因组筛选识别在肿瘤细胞球体培养潜在的新药物靶标
JoVE Journal
Pesquisa do Câncer
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JoVE Journal Pesquisa do Câncer
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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利用功能基因组筛选识别在肿瘤细胞球体培养潜在的新药物靶标

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07:48 min

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December 26, 2016

DOI:

10.3791/54738-v

DOI:
10.3791/54738-v

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07:48 min
December 26, 2016

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1The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer,The Institute of Cancer Research, 2Division of Molecular Pathology,The Institute of Cancer Research, 3Institute of Cancer Sciences,University of Manchester

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Functional GenomicsSiRNA ScreenCancer Cell Spheroid3D CultureHypoxiaTargeted ScreenOncogenesTumor SuppressorsCell ViabilityApoptosisTransfectionCell CultureCell CountingHigh-throughput Screening

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Morrison, E., Wai, P., Leonidou, A., Bland, P., Khalique, S., Farnie, G., Daley, F., Peck, B., Natrajan, R. Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures. J. Vis. Exp. (118), e54738, doi:10.3791/54738 (2016).

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