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煽动抑郁症状，行为变化和不利健康结果鼠害一个不可预知的慢性轻度应激协议
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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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煽动抑郁症状，行为变化和不利健康结果鼠害一个不可预知的慢性轻度应激协议

21,900 Views

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06:55 min

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December 02, 2015

DOI:

10.3791/53109-v

DOI:
10.3791/53109-v

•

06:55 min
December 02, 2015

•

15 Views
, , ,
1Department of Physiology and Pharmacology,West Virginia University Health Sciences Center, 2Division of Vascular and Endovascular Surgery, Center for Cardiovascular and Respiratory Sciences,West Virginia University Health Sciences Center

Summary

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The unpredictable chronic mild stress (UCMS) protocol is a validated method for studying behavioral and physiological changes associated with chronic stress and depressive symptoms. Eight weeks of imposition of the UCMS protocol induces behavioral changes and poor health outcomes in rodents of either gender.

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Unpredictable Chronic Mild StressUCMSRodent ModelDepressionAnhedoniaGrooming BehaviorLearned HelplessnessHypercortisolemiaHypertensionSSRIBehavioral ChangesNegative Health OutcomesCardiovascular System

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Cite this Article

Frisbee, J. C., Brooks, S. D., Stanley, S. C., d'Audiffret, A. C. An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents. J. Vis. Exp. (106), e53109, doi:10.3791/53109 (2015).

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