This report provides a detailed description of transplanting murine thymi from different aged donor mice under the kidney capsule of immunodeficient mouse recipients. The goal of this approach is to model T cell development and thymic selection events in vivo.
Morillon II, Y. M., Manzoor, F., Wang, B., Tisch, R. Isolation and Transplantation of Different Aged Murine Thymic Grafts.. J. Vis. Exp. (99), e52709, doi:10.3791/52709 (2015).