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吗啡诱发的痛觉过敏和镇痛耐受小鼠中利用热和机械伤害性的评估方式
JoVE Journal
Neurociência
This content is Free Access.
JoVE Journal Neurociência
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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吗啡诱发的痛觉过敏和镇痛耐受小鼠中利用热和机械伤害性的评估方式

DOI:
10.3791/51264-v

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07:23 min

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July 29, 2014

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, , ,
1Biotechnology and Cellular Signalling, UMR 7242 CNRS,Université de Strasbourg

Capítulos

  • 00:05Título
  • 01:24Tail Immersion Test (TIT)
  • 02:39Tail Pressure Test (TPT)
  • 03:31Acute Morphine-induced Analgesia
  • 04:42Chronic Morphine Treatment
  • 05:32Results: Morphine-induced Hyperalgesia and Analgesic Tolerance
  • 06:48Conclusion

Summary

Tadução automática

Tadução automática

我们描述了一个协议，研究阿片类药物引起的痛觉过敏和耐受小鼠的发展。基于对幼稚和吗啡处理的动物的热和机械伤害性反应的测量，它允许以量化的增加疼痛的敏感性（痛觉过敏）和减少在慢性阿片类施用相关镇痛（公差）。

Tags

Opioid-induced HyperalgesiaAnalgesic ToleranceMorphineThermal NociceptionMechanical NociceptionTail-immersion TestTail Pressure TestMouse Model

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