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在脑肿瘤和关节炎的用荧光SAPC-DOPS纳米囊泡体光学成像
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May 02, 2014
DOI:
1Division of Hematology-Oncology, Department of Internal Medicine,University of Cincinnati College of Medicine, 2Division of Human Genetics,University of Cincinnati College of Medicine, 3Department of Radiology,University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children’s Hospital Medical Center,University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center,The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center,The Ohio State University Medical Center
Summary
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我们描述了一种多角度旋转的光学成像（MAROI）系统用于体内定量荧光标记由鞘脂激活蛋白C（SAPC） - dioleoylphosphatidylserine（DOPS），纳米囊泡输送的。用人癌症和关节炎的小鼠模型，我们将演示如何在MAROI信号曲线分析可以用于精确制图和疾病过程的生物学特性。
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Chu, Z., LaSance, K., Blanco, V., Kwon, C., Kaur, B., Frederick, M., Thornton, S., Lemen, L., Qi, X. In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles. J. Vis. Exp. (87), e51187, doi:10.3791/51187 (2014).
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