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Medicine

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JoVE Journal Medicine
Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
 

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

Article DOI: 10.3791/50088-v • 08:26 min • March 24th, 2013
March 24th, 2013 •
1,2, 2,3, 2
1Watson School of Biological Sciences, 2Cold Spring Harbor Laboratory, 3Departments of Medical Genetics, University of Oslo and Oslo University Hospital

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Resumo
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We describe a method for imaging response to anti-cancer treatment in vivo and at single cell resolution.

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Live Imaging Drug Responses Tumor Microenvironment Mouse Models Breast Cancer Tumor-stroma Interactions Anti-cancer Therapies Three-dimensional Co-culture Systems In Vivo In Vitro Settings Direct Visualization Real-time Spinning Disk Confocal Microscopy Anesthetized Mice Drug Distribution Cancer Cell Responses Tumor-stroma Interactions Systemic Therapy Breast Cancer Models Labeling Tumor Components Therapeutic Responses Surgical Procedure Imaging Up To 40 Hours Time-lapse Movies Drug Infiltration Cancer Cell Death Stromal Cell Migration Image Analysis Software
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