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利用磁共振成像，容积电脑断层扫描及超音波的裸鼠乳腺癌骨转移大鼠模型血管生成的多模态成像
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Medicina
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JoVE Journal Medicina
Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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利用磁共振成像，容积电脑断层扫描及超音波的裸鼠乳腺癌骨转移大鼠模型血管生成的多模态成像

DOI:
10.3791/4178-v

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12:23 min

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August 14, 2012

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, , ,
1Department of Medical Physics in Radiology,German Cancer Research Center, Heidelberg, Germany, 2Unit of Chemotherapy and Toxicology,German Cancer Research Center, Heidelberg, Germany

Capítulos

  • 00:05Título
  • 01:25Cell Culture
  • 02:00Nude Rat Model of Bone Metastasis
  • 04:10Magnetic Resonance Imaging (MRI)
  • 05:09Volumetric Computed Tomography (VCT)
  • 05:54Ultrasound (US)
  • 07:06Postprocessing of Imaging Data
  • 08:55Results: Multi-modal Imaging of Angiogenesis
  • 11:57Conclusion

Summary

Tadução automática

Tadução automática

在骨转移的发病机制，血管生成是一个关键的过程，因此代表了成像和治疗的目标。在这里，我们提出了一个特定地点的乳腺癌骨转移动物模型和描述战略，以非侵入性影像血管生成<em>在体内</em>使用磁共振成像，容积CT和超声。

Tags

Multi-modal ImagingAngiogenesisNude Rat ModelBreast Cancer Bone MetastasisMagnetic Resonance ImagingVolumetric Computed TomographyUltrasoundExperimental Bone MetastasisIn Vivo AssessmentNon-invasive Imaging TechniquesMDA-MB-231 Human Breast Cancer CellsEpigastric Artery InjectionSite-specific Bone MetastasesDistal FemurProximal TibiaProximal FibulaMorphological Aspects Of AngiogenesisFunctional Aspects Of AngiogenesisDynamic Contrast-enhanced MRI (DCE-MRI)Regional Blood VolumePerfusionVessel Permeability

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