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Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
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Medicina
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JoVE Journal Medicina
Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

14,201 Views

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11:24 min

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October 18, 2011

DOI:

10.3791/3107-v

DOI:
10.3791/3107-v

•

11:24 min
October 18, 2011

•

11 Views
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1Department of Radiation Oncology,University of California Irvine

Summary

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Brain tumor patients routinely undergo cranial radiotherapy, and while beneficial, this treatment often results in debilitating cognitive dysfunction. This serious unresolved problem has at present, no clinical recourse, and has driven our efforts to devise stem cell based therapies for the recovery of radiation-induced cognitive decrements.

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Stem Cell TransplantationCognitive DysfunctionCranial RadiotherapyBrain TumorsNeural Stem CellsRadiation-induced Cognitive DeclineAthymic Nude RatsHippocampusHuman Neural Stem Cells (hNSCs)Cognition ImprovementGrafted Cell SurvivalDifferentiation-specific Markers

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Cite this Article

Acharya, M. M., Roa, D. E., Bosch, O., Lan, M. L., Limoli, C. L. Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy. J. Vis. Exp. (56), e3107, doi:10.3791/3107 (2011).

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