外科口罩对健康受试者心肺功能的影响
1Department of Rehabilitation Medicine,The Fifth Affiliated Hospital of Guangzhou Medical University, 2The Rehabilitation Medicine Lab of Guangzhou Medical University, 3Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery,The Fifth Affiliated Hospital of Guangzhou Medical University, 4Department of Rehabilitation Therapy,Guangzhou Medical University, 5Department of Rehabilitation Medicine,The Sixth Affiliated Hospital of Sun Yat-sun University
Summary
我们基于心肺运动试验 （CPET） 研究了外科口罩对心肺功能的影响。这项研究表明，外科口罩会降低健康年轻受试者的心肺运动能力和通气量，戴口罩可能会对女性受试者的有氧运动能力产生比男性受试者更大的影响。
Abstract
我们基于心肺运动试验 （CPET） 研究了外科口罩对心肺功能的影响。这项研究表明，外科口罩会降低健康年轻受试者的心肺运动能力和通气量，戴口罩可能会对女性受试者的有氧运动能力产生比男性受试者更大的影响。
Introduction
在公共场所佩戴口罩可以防止吸入传染性飞沫及其随后的呼出和传播，从而阻止传染病的传播1.尽管降低呼吸道病毒传播风险的效果仍然存在争议，但戴口罩仍然是社区中人们选择防止飞沫在日常生活中传播的主要方式之一2,3,4。
不同类型的面膜对增加呼气阻力和吸气阻力有不同的作用5.同时，在呼吸道疾病大流行期间，人们（包括健康人和心肺疾病患者）可能需要长时间佩戴口罩才能进行日常活动。然而，关于戴口罩对心肺功能影响的研究很少。
心肺运动试验（CPET）是心血管康复风险评估的重要手段，它反映了运动负荷增加时机体心肺功能的各种参数，被认为是心肺储备试验的金标准2。我们使用不同条件下（戴口罩和不戴口罩）的CPET来研究健康年轻受试者心肺功能参数的变化，从新颖的方法论角度客观定量地评估口罩对心肺储备和运动耐力的干扰，以指导口罩在特别是呼吸道传染病大流行中的应用。虽然FFP2/N95被认为在减少病毒感染方面比外科口罩更有效，但医用外科口罩比FFP2/N95口罩更方便、更常见。因此，本研究仅关注医用外科口罩对心肺功能的影响。
Protocol
该临床项目获得广州医科大学附属第五医院医学伦理学会（No.KY01-2020-06-06），并已在中国临床试验注册中心注册（No.ChiCTR2000033449），标题为“口罩对心肺和下肢功能的影响”。 1. 参与者招募 包括 18 至 26 岁的受试者：可以通过 PAR-Q 测试6;身体健康;没有专业的运动训练经验;并能理解实验，并自愿配合整个测试过程。 排除受试者：患有心血管?…
Representative Results
本研究招募了广州医科大学康复医学系的10名受试者（5男5女）。受试者具有相似的基线特征，例如年龄（平均年龄：男性21.00岁±1.58岁;女性21.20岁±0.45岁）和身体素质[体育活动和体重指数（BMI）]。男性和女性组在年龄、身高或BMI方面没有显著差异。此外，在肺活量测定方面，与男性组相比，女性组的FVC更低，用力呼气容积（FEV1）更低，MVV更低，呼气峰流量（PEF）更低（<…
Discussion
CPET 为心血管、通气和骨骼肌系统的综合功能提供了宝贵的见解13.我们提出了关于戴口罩和戴口罩条件的 CPET 方案，以探索外科口罩对健康年轻受试者心肺功能的影响。
该协议的设计基于三个要点。首先，我们招募了年轻健康的大学生作为研究对象，因为在戴口罩的情况下，CPET的强度相对较高，身体素质也差不多。其次，根据肺活量测定结果和既往研究，?…
Declarações
The authors have nothing to disclose.
Acknowledgements
本研究得到了国家自然科学青年科学基金（第81902281号）的资助;广州市卫生计生委（20191A0011091、20201A011108）、广东省教育厅（2019KQNCX119）、广州市重点实验室基金（201905010004）总体指导项目。本研究还感谢广州医科大学的张立新、阮培林、季凯航和古利菲亚·图尔迅的数据收集。
Materials
| Cardiopulmonary test system | COSMED Srl – Italy | K4b2 | Pulmonary Function Equipment |
| Cycle for CPET | COSMED Srl – Italy | ergoline 100P | cycle ergometer 100 P w/BP |
| Eectrocardiograph | COSMED Srl – Italy | Quark T12x | 12-Channel ECG Street Test Unit |
| Mask | COSMED Srl – Italy | Small,Medium,Large | V2 Mask |
| Software | COSMED Srl – Italy | PFT SUITE | PC Software |
| Surgical masks |
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Citar este artigo
Li, M., Ou, H., Li, Q., Liang, J., Liao, W., Lang, S., Chen, H., Wang, Y., Tang, K., Lin, Q., Zheng, Y. Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects. J. Vis. Exp. (168), e62121, doi:10.3791/62121 (2021).