सुनवाई थ्रेसहोल्ड तरह मापदंडों सुनवाई, सुनवाई impairments या प्रेत धारणा (व्यक्तिपरक tinnitus) के व्यवहार निर्धारण करने के लिए एक तेजी से और सस्ती विधि का वर्णन है. यह पूर्व ध्वनिक डराना प्रतिक्रिया के निषेध नाड़ी का उपयोग करता है और आसानी से एक व्यक्तिगत एक प्रोग्राम ई. / डीए कनवर्टर और एक piezo सेंसर का उपयोग कर कंप्यूटर में लागू किया जा सकता है.
In auditory animal research it is crucial to have precise information about basic hearing parameters of the animal subjects that are involved in the experiments. Such parameters may be physiological response characteristics of the auditory pathway, e.g. via brainstem audiometry (BERA). But these methods allow only indirect and uncertain extrapolations about the auditory percept that corresponds to these physiological parameters. To assess the perceptual level of hearing, behavioral methods have to be used. A potential problem with the use of behavioral methods for the description of perception in animal models is the fact that most of these methods involve some kind of learning paradigm before the subjects can be behaviorally tested, e.g. animals may have to learn to press a lever in response to a sound. As these learning paradigms change perception itself 1,2 they consequently will influence any result about perception obtained with these methods and therefore have to be interpreted with caution. Exceptions are paradigms that make use of reflex responses, because here no learning paradigms have to be carried out prior to perceptual testing. One such reflex response is the acoustic startle response (ASR) that can highly reproducibly be elicited with unexpected loud sounds in naïve animals. This ASR in turn can be influenced by preceding sounds depending on the perceptibility of this preceding stimulus: Sounds well above hearing threshold will completely inhibit the amplitude of the ASR; sounds close to threshold will only slightly inhibit the ASR. This phenomenon is called pre-pulse inhibition (PPI) 3,4, and the amount of PPI on the ASR gradually depends on the perceptibility of the pre-pulse. PPI of the ASR is therefore well suited to determine behavioral audiograms in naïve, non-trained animals, to determine hearing impairments or even to detect possible subjective tinnitus percepts in these animals. In this paper we demonstrate the use of this method in a rodent model (cf. also ref. 5), the Mongolian gerbil (Meriones unguiculatus), which is a well know model species for startle response research within the normal human hearing range (e.g. 6).
हम कृन्तकों में audiometric माप के लिए एक सस्ता और आसान बनाने के लिए सेटअप पूर्व पल्स ध्वनिक डराना प्रतिक्रिया है कि व्यवहार सुनवाई (= 10 audiograms) थ्रेसहोल्ड और श्रवण की तरह व्यक्तिपरक tinnitus 11 प्रेत विचारों का …
The authors have nothing to disclose.
यह काम अरलैंगेन नूर्नबर्ग के विश्वविद्यालय के विश्वविद्यालय अस्पताल में क्लीनिकल रिसर्च के लिए अंतःविषय केंद्र (IZKF, E7 परियोजना) द्वारा समर्थित किया गया.