Exertional Heat Stroke Mouse Model: A Protocol to Study Mechanisms Underlying Exertional Heat Stroke
Published: April 30, 2023
Abstract
Source: King, M. A. et al. A Preclinical Model of Exertional Heat Stroke in Mice. J. Vis. Exp. (2021).
In this video we describe a step-by-step protocol to study exertional heat stroke (EHS) in a mouse model.
Protocol
All procedures involving animal models have been reviewed by the local institutional animal care committee and the JoVE veterinary review board. 1. EHS Protocol The night before the EHS protocol, place the mouse in the environmental chamber at room temperature (~25 °C, ≈30% relative humidity) to acclimate to the chamber. Use a data acquisition system to collect continuous core temperature (Tc), averaged over 30 s intervals overnight. …
Declarações
The authors have nothing to disclose.
Materials
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Exertional Heat Stroke Mouse Model: A Protocol to Study Mechanisms Underlying Exertional Heat Stroke. J. Vis. Exp. (Pending Publication), e20747, doi: (2023).