Chapter 25
The Cytoskeleton I: Actin and Microfilaments
![Introduction to the Cytoskeleton](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11788.jpg)
Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments…
![Adaptability of Cytoskeletal Filaments](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11789.jpg)
The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual…
![Assembly of Cytoskeletal Filaments](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11791.jpg)
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or…
![Cytoskeletal Linker Proteins - Plakins](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11792.jpg)
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes…
![Cytoskeletal Proteins in Bacteria](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11794.jpg)
Bacterial cells were initially considered simple, randomly organized structures lacking a cytoskeleton. However, the discovery of cytoskeleton…
![Intracellular Movement of Viruses and Bacteria](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11795.jpg)
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include…
![Introduction to Actin](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11797.jpg)
Actin is a highly conserved cytoskeletal protein found abundantly in eukaryotic cells. It constitutes 10% weight of the total cellular protein in…
![Actin Polymerization](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11798.jpg)
Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The…
![Generation of Straight or Branched Actin Filaments](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11799.jpg)
The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex.…
![Actin Filament Depolymerization](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11800.jpg)
Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of…
![Overview of Myosin Structure and Function](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11802.jpg)
Myosins are a family of molecular motor proteins, first identified in the skeletal muscles, where they are responsible for muscle contraction. Along…
![Actin and Myosin in Muscle Contraction](https://jovecdn2.ccindex.cn/files/media/science-education/science-education-thumbs/11803.jpg)
Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a…
![Study of the Actin Cytoskeleton in Live Endothelial Cells Expressing GFP-Actin](https://jovecdn2.ccindex.cn/files/thumbs/3187_t.png)
Study of the Actin Cytoskeleton in Live Endothelial Cells Expressing GFP-Actin
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The microvascular endothelium plays an important role as a selectively permeable barrier to fluids and solutes. The adhesive junctions between…
![X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease](https://jovecdn2.ccindex.cn/files/thumbs/59559_t.png)
X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
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Transgenic mouse models have been important tools for studying the relationship of genotype to phenotype for human diseases including those of…