Seoul National University Bundang Hospital 8 articles published in JoVE Medicine Reliability of Artificial Intelligence-Based Cone Beam Computed Tomography Integration with Digital Dental Images Ju-Heon Lee*1, Nam-Ki Lee*1, Bingshuang Zou2, Jae Hyun Park3,4, Tae-Hyun Choi1 1Department of Orthodontics, Seoul National University Bundang Hospital, 2Division of Orthodontics, Faculty of Dentistry, University of British Columbia, 3Postgraduate Orthodontic Program, Arizona School of Dentistry & Oral Health, A. T. Still University, 4Graduate School of Dentistry, Kyung Hee University A process of registering cone-beam computed tomography scans and digital dental images has been presented using artificial intelligence (AI) -assisted identification of landmarks and merging. A comparison with surface-based registration shows that AI-based digitization and integration are reliable and reproducible. Neuroscience Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke Ga-Young Choi*1, Won Kee Chang*2, Miseon Shim1, Nuri Kim2, Ji-hee Jang2, Won-Seok Kim2, Han-Jeong Hwang1,3, Nam-Jong Paik2 1Department of Electronics and Information Engineering, Korea University, 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 3Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology, Korea University The experimental protocol demonstrates the paradigm for acquiring and analyzing electroencephalography (EEG) signals during upper limb movement in individuals with stroke. The alteration of the functional network of low-beta EEG frequency bands was observed during the movement of the impaired upper limb and was associated with the degree of motor impairment. Medicine Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window Inwon Park1, Pilhan Kim2,3 1Department of Emergency Medicine, Seoul National University Bundang Hospital, 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, 3KI for Health Science and Technology, Korea Advanced Institute of Science and Technology In vivo high-resolution imaging of the pancreas was facilitated with the pancreatic intravital imaging window. Medicine Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults Sungmin Cho*1, Won-Seok Kim*2, Seo Hyun Park2, Jihong Park2, Nam-Jong Paik2 1Delvine Inc., 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital This experimental protocol demonstrates the use of virtual prism adaptation therapy (VPAT) in healthy adults and the association between VPAT and functional near infrared spectroscopy to determine the effect of VPAT on cortical activation. Results suggest that VPAT may be feasible and could induce similar behavioral adaptation as conventional prism adaptation therapy. Behavior Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation Yoon-Hee Choi1,2, Nam-Jong Paik1 1Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 2Department of Physical Medicine and Rehabilitation, Soonchunhyang University College of Medicine, Soonchunhyang University Hospital Here, we present a protocol to develop and apply a mobile game-based virtual reality program for the recovery of upper limb dysfunction in patients with stroke. The present study shows that the mobile program is feasible and effectively promotes upper limb recovery in stroke patients. Medicine Reproducible Motor Deficit Following Aortic Occlusion in a Rat Model Of Spinal Cord Ischemia Jin-Young Hwang1, Hye-Min Sohn2, Jin-Hee Kim2, Seongjoo Park2, Jin-Woo Park2, Mi-Sun Lim2, Sung-Hee Han2 1Department of Anesthesiology and Pain Medicine, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, 2Department of Anesthesiology and Pain Medicine, SNU Bundang Hospital, Seongnamsi, Gyeonggido, Republic of Korea This study demonstrates the technique to make a minimally invasive and easily reproducible model of spinal cord ischemia in rats. Various degrees of hind limb motor deficit can be produced by controlling the aortic occlusion time. Cancer Research Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles Ji-Eun Chang1, Hyun-Jong Cho2, Sanghoon Jheon1,3 1Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, 2College of Pharmacy, Kangwon National University, 3Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine Photodynamic therapy (PDT) is an alternative choice for lung cancer treatment. To increase the therapeutic effect of PDT, lung cancer-targeted nanoparticles combined with chemotherapy were developed. Both in vitro and in vivo anticancer efficacies of PDT with prepared nanoparticles were evaluated. Medicine Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs Seong Joon Ahn1,2,3, Hye Kyoung Hong1, Young Mi Na1, Sang Jun Park1,2, Jeeyun Ahn1,2,4, Jaeseong Oh5, Jae Yong Chung6, Kyu Hyung Park1,2, Se Joon Woo1,2 1Department of Ophthalmology, Seoul National University Bundang Hospital, 2Department of Ophthalmology, College of Medicine, Seoul National University, 3Department of Ophthalmology, Hanyang University Hospital, 4Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 5Department of Clinical Pharmacology, Seoul National University Hospital, 6Department of Clinical Pharmacology, Seoul National University Bundang Hospital Rabbits are widely used to study the pharmacokinetics of intraocular drugs. We describe a method for conducting pharmacokinetic studies of intraocular drugs using rabbit eyes.
