Coculturing AdMSCs and Glia to Reduce Prion-Induced Inflammation

Coculturing AdMSCs and Glia to Reduce Prion-Induced Inflammation

August 11, 2023

脂肪来源的间充质基质细胞与原代混合胶质细胞共培养，以减少朊病毒诱导的炎症

用朊病毒分离和感染原代皮质混合胶质胶质细胞

小鼠脂肪来源的间充质基质细胞的迁移测定

Arielle J. D. Hay^1,2, Katriana A. Popichak^1,2, Mark D. Zabel^1,2, Julie A. Moreno^1,3

¹Prion Research Center,Colorado State University, ²Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences,Colorado State University, ³Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences,Colorado State University

Summary

脂肪来源的间充质基质细胞（AdMSC）具有有效的免疫调节特性，可用于治疗与炎症相关的疾病。我们演示了如何分离和培养小鼠 AdMSCs 和原代混合胶质细胞，刺激 AdMSCs 上调抗炎基因和生长因子，评估 AdMSCs 的迁移，以及将 AdMSCs 与原代混合朊病毒感染的神经胶质细胞共培养。

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