Jesús Jiménez-Barbero CIC bioGUNE, Basque Research and Technology Alliance (BRTA) Biography Publications Institution JoVE Articles Jesús Jiménez-Barbero has not added a biography. If you are Jesús Jiménez-Barbero and would like to personalize this page please email our Author Liaison for assistance. Publications Strategy for the Enzymatic Acylation of the Apple Flavonoid Phloretin Based on Prior α-Glucosylation Journal of Agricultural and Food Chemistry. Feb, 2024 | Pubmed ID: 38350922 Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 Via NMR Spectroscopy and Molecular Dynamics Modeling ACS Chemical Biology. Feb, 2024 | Pubmed ID: 38321945 Correction to "Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection" ACS Omega. Jan, 2024 | Pubmed ID: 38313499 The Impact of Glycosylation on the Structure, Function, and Interactions of CD14 Glycobiology. Apr, 2024 | Pubmed ID: 38227775 Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection ACS Omega. Nov, 2023 | Pubmed ID: 38027314 Identification of a New DC-SIGN Binding Pentamannoside Epitope Within the Complex Structure of Mannan Cell Surface (Amsterdam, Netherlands). Dec, 2023 | Pubmed ID: 37520856 Structural Insights into Siglec-15 Reveal Glycosylation Dependency for Its Interaction with T Cells Through Integrin CD11b Nature Communications. Jun, 2023 | Pubmed ID: 37311743 Total Synthesis and Structural Studies of Zwitterionic Polysaccharide A1 Fragments Journal of the American Chemical Society. Jun, 2023 | Pubmed ID: 37310804 Molecular Recognition of Glycan-Bearing Glycomacromolecules Presented at Membrane Surfaces by Lectins: An NMR View ACS Omega. May, 2023 | Pubmed ID: 37214724 Highly Diastereoselective Multicomponent Synthesis of Spirocyclopropyl Oxindoles Enabled by Rare-Earth Metal Salts Organic Letters. May, 2023 | Pubmed ID: 37125666 Development of Synthetic, Self-adjuvanting, and Self-assembling Anticancer Vaccines Based on a Minimal Saponin Adjuvant and the Tumor-associated MUC1 Antigen Chemical Science. Mar, 2023 | Pubmed ID: 37006677 New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity As Vaccine Adjuvants Journal of Medicinal Chemistry. Feb, 2023 | Pubmed ID: 36728697 Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin ACS Central Science. Oct, 2022 | Pubmed ID: 36313162 The Spike of SARS-CoV-2 Promotes Metabolic Rewiring in Hepatocytes Communications Biology. Aug, 2022 | Pubmed ID: 35978143 Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods Frontiers in Microbiology. 2022 | Pubmed ID: 35495643 Atomic and Specificity Details of Mucin 1 -Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling JACS Au. Mar, 2022 | Pubmed ID: 35373202 Unveiling the Role of Pyrylium Frameworks on π-stacking Interactions: a Combined and Experimental Study Physical Chemistry Chemical Physics : PCCP. Jan, 2022 | Pubmed ID: 34633001 Sulfation Code and Conformational Plasticity of L-Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate ACS Chemical Biology. Nov, 2021 | Pubmed ID: 34586794 Targeting Transthyretin in Alzheimer's Disease: Drug Discovery of Small-molecule Chaperones As Disease-modifying Drug Candidates for Alzheimer's Disease European Journal of Medicinal Chemistry. Dec, 2021 | Pubmed ID: 34555615 Epitope Recognition of a Monoclonal Antibody Raised Against a Synthetic Glycerol Phosphate Based Teichoic Acid ACS Chemical Biology. Aug, 2021 | Pubmed ID: 34255482 Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers International Journal of Molecular Sciences. Jun, 2021 | Pubmed ID: 34206141 The Two Domains of Human Galectin-8 Bind Sialyl- and Fucose-containing Oligosaccharides in an Independent Manner. A 3D View by Using NMR RSC Chemical Biology. Apr, 2021 | Pubmed ID: 34179785 Selective C-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes Through NMR: Polylactosamine Binding to Galectins Angewandte Chemie (International Ed. in English). Aug, 2021 | Pubmed ID: 34128568 Hypoxia Reduces Cell Attachment of SARS-CoV-2 Spike Protein by Modulating the Expression of ACE2, Neuropilin-1, Syndecan-1 and Cellular Heparan Sulfate Emerging Microbes & Infections. Dec, 2021 | Pubmed ID: 34013835 Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens With Different Peripheral Core Presentations Frontiers in Chemistry. 2021 | Pubmed ID: 33968903 Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions Accounts of Chemical Research. Jun, 2021 | Pubmed ID: 33930267 Exploration of Galectin Ligands Displayed on Gram-Negative Respiratory Bacterial Pathogens with Different Cell Surface Architectures Biomolecules. Apr, 2021 | Pubmed ID: 33919637 Minimal Epitope for Mannitou IgM on Paucimannose-carrying Glycoproteins Glycobiology. Sep, 2021 | Pubmed ID: 33909073 Synthesis and Chelation Study of a Fluoroionophore and a Glycopeptide Based on an Aza Crown Iminosugar Structure Carbohydrate Research. Mar, 2021 | Pubmed ID: 33618101 NMR of Glycoproteins: Profiling, Structure, Conformation and Interactions Current Opinion in Structural Biology. Jun, 2021 | Pubmed ID: 33129067 Bacterial Polysaccharides: Conformation, Dynamics and Molecular Recognition by Antibodies Drug Discovery Today. Technologies. Dec, 2020 | Pubmed ID: 33388123 Current Status on Therapeutic Molecules Targeting Siglec Receptors Cells. Dec, 2020 | Pubmed ID: 33333862 Fluorinated Carbohydrates As Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by F NMR Spectroscopy The Journal of Organic Chemistry. Dec, 2020 | Pubmed ID: 33258593 Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and Their Interactions with Human Lectins Angewandte Chemie (International Ed. in English). Dec, 2020 | Pubmed ID: 32915505 Synthesis of Long-chain Alkyl Glucosides Via Reverse Hydrolysis Reactions Catalyzed by an Engineered β-glucosidase Enzyme and Microbial Technology. Oct, 2020 | Pubmed ID: 32912700 Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-β Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in Vivo Molecular Imaging Study1 Journal of Alzheimer's Disease : JAD. 2020 | Pubmed ID: 32804152 Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1 Chemistry (Weinheim an Der Bergstrasse, Germany). Dec, 2020 | Pubmed ID: 32780906 An Assay for Screening Potential Drug Candidates for Alzheimer's Disease That Act As Chaperones of the Transthyretin and Amyloid-β Peptides Interaction Chemistry (Weinheim an Der Bergstrasse, Germany). Dec, 2020 | Pubmed ID: 32761825 The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations Pharmaceuticals (Basel, Switzerland). Aug, 2020 | Pubmed ID: 32759765 Structural Basis of Noscapine Activation for Tubulin Binding Journal of Medicinal Chemistry. Aug, 2020 | Pubmed ID: 32657585 Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity ACS Chemical Biology. Jul, 2020 | Pubmed ID: 32584537 Fluorinated Carbohydrates As Chemical Probes for Molecular Recognition Studies. Current Status and Perspectives Chemical Society Reviews. Jun, 2020 | Pubmed ID: 32520059 An Epoxide Intermediate in Glycosidase Catalysis ACS Central Science. May, 2020 | Pubmed ID: 32490192 Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin Chembiochem : a European Journal of Chemical Biology. Nov, 2020 | Pubmed ID: 32426893 Structure-Guided Design of a Group B Streptococcus Type III Synthetic Glycan-Conjugate Vaccine Chemistry (Weinheim an Der Bergstrasse, Germany). Jun, 2020 | Pubmed ID: 32390224 Chemoenzymatic Synthesis of 3-deoxy-3-fluoro-l-fucose and Its Enzymatic Incorporation into Glycoconjugates Chemical Communications (Cambridge, England). Jun, 2020 | Pubmed ID: 32390019 Synthesis and Structural Analysis of Aspergillus Fumigatus Galactosaminogalactans Featuring α-Galactose, α-Galactosamine and α-N-Acetyl Galactosamine Linkages Angewandte Chemie (International Ed. in English). Jul, 2020 | Pubmed ID: 32342633 Selective Synthesis of Galactooligosaccharides Containing β(1→3) Linkages with β-Galactosidase from (Saphera) Journal of Agricultural and Food Chemistry. Apr, 2020 | Pubmed ID: 32279499 Calorimetric Studies of Binary and Ternary Molecular Interactions Between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones Toward an Alternative Strategy for Alzheimer's Disease Drug Discovery Journal of Medicinal Chemistry. Mar, 2020 | Pubmed ID: 32124607 Structure-Guided Design of a Group B Streptococcus Type III Synthetic Glycan-Conjugate Vaccine Chemistry (Weinheim an Der Bergstrasse, Germany). Jun, 2020 | Pubmed ID: 32058627 Glycans in Drug Discovery MedChemComm. Oct, 2019 | Pubmed ID: 31814952 Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates Molecules (Basel, Switzerland). Jun, 2019 | Pubmed ID: 31242623 Optimization of Regioselective α-Glucosylation of Hesperetin Catalyzed by Cyclodextrin Glucanotransferase Molecules (Basel, Switzerland). Nov, 2018 | Pubmed ID: 30400664 Enzymatic Synthesis of a Novel Pterostilbene α-Glucoside by the Combination of Cyclodextrin Glucanotransferase and Amyloglucosidase Molecules (Basel, Switzerland). May, 2018 | Pubmed ID: 29799509 The Recognition of Glycans by Protein Receptors. Insights from NMR Spectroscopy Chemical Communications (Cambridge, England). May, 2018 | Pubmed ID: 29662983 Interactions Between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods International Journal of Molecular Sciences. Jun, 2017 | Pubmed ID: 28629128 Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones) Molecules (Basel, Switzerland). Aug, 2016 | Pubmed ID: 27527129 Conformational Flexibility Around the Gal-β-(1 → 3)-Glc Linkage: Experimental Evidence for the Existence of the Anti-ψ Conformation in Aqueous Solution Carbohydrate Research. Oct, 2016 | Pubmed ID: 27434833 Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation As Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella Flexneri 3a Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2016 | Pubmed ID: 27376496 Fluorinated Carbohydrates As Lectin Ligands: (19)F-Based Direct STD Monitoring for Detection of Anomeric Selectivity Biomolecules. Nov, 2015 | Pubmed ID: 26580665 Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH-π Interactions Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2015 | Pubmed ID: 26177718 Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2015 | Pubmed ID: 26096911 Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2015 | Pubmed ID: 26095198 Glycans in Medicinal Chemistry: An Underexploited Resource ChemMedChem. Aug, 2015 | Pubmed ID: 25974358 Structure and Function of Prokaryotic UDP-Glucose Pyrophosphorylase, A Drug Target Candidate Current Medicinal Chemistry. 2015 | Pubmed ID: 25620104 Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition Sara Bertuzzi1, Ana Poveda1, Ana Ardá1,2, Ana Gimeno1,2, Jesús Jiménez-Barbero1,2,3 1CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 2lkerbasque, Basque Foundation for Science, 3Centro de Investigacion Biomedica En Red de Enfermedades Respiratorias JoVE 66530 Química
Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition Sara Bertuzzi1, Ana Poveda1, Ana Ardá1,2, Ana Gimeno1,2, Jesús Jiménez-Barbero1,2,3 1CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 2lkerbasque, Basque Foundation for Science, 3Centro de Investigacion Biomedica En Red de Enfermedades Respiratorias JoVE 66530 Química