Evaluating the Function of the Foot Core System in the Elderly

Zhangqi Lai; Xiaoyue Hu; Li Xu; Kun Dong; Lin Wang

doi:10.3791/63479

JoVE Journal > Neuroscience

Neurociência

Evaluating the Function of the Foot Core System in the Elderly

Published: March 11, 2022

doi:

10.3791/63479

Zhangqi Lai¹, Xiaoyue Hu¹, Li Xu¹, Kun Dong¹, Lin Wang¹

¹Shanghai Frontiers Science Research Base of Exercise and Metabolic Health,Shanghai University of Sport

Summary

The functional core stability of the foot contributes to the human static posture and dynamic activities. This paper proposes a comprehensive evaluation for the function of the foot core system, which combines three subsystems. It may provide increased awareness and multifaceted protocol to explore the foot function among different populations.

Abstract

As a complex structure to link the body and the ground, the foot contributes to postural control in human static and dynamic activities. The foot core is rooted in the functional interdependence of the passive, active, and neural subsystems, which combine into the foot core system controlling foot motion and stability. The foot arch (passive subsystem), responsible for load, is considered the functional core of the foot, and its stability is necessary for normal foot functions. The functional abnormalities of the foot have been widely reported in the elderly, such as weakness of toe flexor muscles, abnormal foot postures, and decreased plantar sensory sensitivity. In this paper, a comprehensive approach is introduced for evaluating the foot function based on foot core subsystems. The strength and morphology of the foot intrinsic and extrinsic muscles were used to evaluate the foot muscle (active subsystem) function. The doming strength test was applied to determine the function of foot intrinsic muscles, while the toe flexion strength test focused more on the function of extrinsic muscles. The navicular drop test and foot posture index were applied to evaluate foot arch (passive subsystem) function. For the neural subsystem, the plantar light touch threshold test and two-point discrimination test were used to assess plantar tactile sensitivity at nine regions of the foot. This study provides new insights into the foot core function in the elderly and other populations.

Introduction

The human foot is a highly complex structure, consisting of bones, muscles, and tendons that attach to the foot. As a segment of the lower extremity, the foot constantly provides direct source contact with the supporting surface and hence contributes to weight-bearing tasks¹. Based on the complex biomechanical interplay between muscles and passive structures, the foot contributes to shock absorption, adjusts for irregular surfaces, and generates momentum. Evidence shows that the foot contributes meaningfully to postural stability, walking, and running²^,³^,⁴.

According to a new paradigm proposed by McKeon⁵ in 2015, the foot core is rooted in the functional interdependence of the passive, active, and neural subsystems, which combine into the foot core system controlling foot motion and stability. In this paradigm, the foot bony anatomy forms the functional half dome, which includes the longitudinal arches and transverse metatarsal arches and flexibly adapts to load changes⁶. This half dome and passive structures, including the ligaments and joint capsules, constitute the passive subsystem. Additionally, the active subsystem consists of foot intrinsic muscles, extrinsic muscles, and tendons. The intrinsic muscles act as local stabilizers responsible for supporting the foot arches, load dependence, and modulation⁷^,⁸, while the extrinsic muscles generate foot motion as global movers. For the neural subsystem, several kinds of sensory receptors (e.g., capsuloligamentous and cutaneous receptors) in the plantar fascia, ligaments, joint capsules, muscles, and tendons contribute to foot dome deformation, gait, and balance⁹^,¹⁰.

Several researchers have speculated that the foot contributes to daily activities in two main ways. One is by mechanical support via the functional arch and the modulation among lower limb muscles. The other is the input of plantar sensory information about the position¹¹. Based on the foot core system, deficits in this system, including foot posture, the strength of intrinsic and extrinsic foot muscles, and sensation sensibility, may predispose to the weakness of mobility and balance⁹^,¹¹^,¹²^,¹³.

However, with advancing age, alterations to the aspect, biomechanics, structure, and function of the foot commonly occur, including foot or toe deformities, weakness of foot or toe strength, plantar pressure distribution, and reduced plantar tactile sensitivity¹⁴^,¹⁵^,¹⁶^,¹⁷. The presence of toe deformity and the severity of hallux valgus are associated with mobility and fall risk in the elderly¹¹^,¹⁸. Moreover, the strength of toe flexor muscles, which used to be overlooked, contributes to balance in elderly people¹⁹. Meanwhile, the elderly are also at higher risks to have foot conditions associated with pathologies such as diabetes, peripheral arterial disease, neuropathy, and osteoarthritis²⁰^,²¹.

The assessment, examination, and health care of the foot, especially in the elderly, have attracted increasing attention¹⁴^,²¹. However, there is a limited study to explore the comprehensive evaluation for the function of the foot core system. Numerous studies aimed to explore foot pathological problems in the elderly, such as pain and nail, skin, bone/joint, and neurovascular disorders²¹^,²²^,²³. The role of the foot in mechanical support and sensory input during daily activities and as a functional core system needs to be recognized and evaluated, which was ignored in previous studies. Especially, the foot active components, including the intrinsic and extrinsic muscles, works as the local stabilizers and global movers and contribute to the foot stability and behavior in static posture and dynamic movement⁵.

The toe flexion strength is singularly reported to represent foot muscle strength, and it's also utilized to explore the relationship between foot function and other health situations, such as balance, and mobility²⁴^,²⁵^,²⁶. Inherently, the foot muscle strength is limited to distinguishing the action of intrinsic and extrinsic muscles. Moreover, several tests, including the paper grip test and an intrinsic positive test, were criticized as non-quantitative tests that have poor reliability and validity⁷^,²⁷. Recently, a new evaluation of foot doming strength was reported to quantify the intrinsic foot muscle strength and it has been shown to have a good validity²⁸. By measuring the doming (short-foot movement) strength, it contributes to directly quantifying the function of intrinsic muscle.

Therefore, a protocol is proposed here aiming to explore the characteristics of the foot in the elderly based on the foot core system, especially the function of the active subsystem. This protocol provides a comprehensive assessment to investigate foot core stability, including the passive, active, and neural subsystem, in the elderly. Moreover, alterations in foot core function have been reported in several health situations, such as plantar fasciitis, flat foot, and diabetes²⁴^,²⁹^,³⁰. In the future studies, it might help to evaluate the foot function among different populations in a multidimensional measurement.

Protocol

This study was conducted at the Sports Medicine and Rehabilitation Centre, Shanghai University of Sport, and has been approved by the ethics committee of the Shanghai University of Sport (No. 102772020RT001). Before the test, the participants were given details about the experimental purpose and procedures; all participants signed the informed consent.

1. Participant selection

Include participants who (1) are aged over 60 years old; (2) can maintain standing position alone; (3) can walk independently, without help from others, prosthesis, or mobility aids; (4) can display normal cognitive function and can understand the procedures and instructions of the test. Exclude participants who (1) were diagnosed with severe cardiopulmonary disease; (2) diagnosed with motor neuron disorders, such as Alzheimer's disease and Parkinson's disease; and (3) had a history of lower limb trauma in the past year were excluded.
NOTE: To evaluate the function of the foot core system, 42 elderly participants and 42 young participants whose demographic data matched with the old group (control group) were recruited for this study. The sample size was calculated for t-test with setting of α = 0.05, power (1 − β) = 0.95, and effect size = 0.8. The result shows that 42 participants in each group should be included in this study.

2. Active subsystem

NOTE: The morphology and strength tests of intrinsic and extrinsic foot muscles are used to evaluate the active subsystem.

Muscle morphology
1. Turn on the musculoskeletal ultrasound system, and then click on the Freeze button. Plug the probe connector into the connection port on the rear side of the host and lock the Probe Lock button. Click on the iStation button, and then click on New Patient. Input the ID, name, gender, and date of birth of each participant.
  NOTE: The probe cable should be arranged properly and placed in a location where it will not be easily trampled to ensure that the cable is not entangled with the other objects. Place the probe in a safe location to avoid collision and damage.
2. Abductor hallucis (AbH): Apply the ultrasound coupling gel at the middle of the scanning line of tuberosity and navicular tuberosity. Place the probe at the medial calcaneal tuberosity toward the navicular tuberosity. Move the probe sightly to capture the thickest part of the AbH, and then click on the Save button to save the still image.
  1. Then, rotate the probe 90° to obtain the cross-sectional image of the AbH and save the image.
    NOTE: Maintain good contact between the probe and the skin without applying excessive pressure in muscle morphology measurements.
3. Flexor digitorum brevis (FDB): Align the probe longitudinally on the line from the medial tubercle of the calcaneus to the third toe and scan the muscle to measure the thickness. Rotate the probe 90° to obtain the cross-sectional image.
4. Quadratus plantae (QP): Align the probe longitudinally along the muscle fibers at the talocalcaneonavicular joint. Move the probe sightly to locate the thickest part of QP. Capture three images for thickness measurement. Rotate the probe 90° to obtain cross-sectional images.
  NOTE: QP lies deep in the FDB.
5. Flexor hallucis brevis (FHB): Mark the first metatarsal, apply the ultrasound coupling gel, and then place the probe longitudinally along the shaft. Move the probe sightly to capture the thickest part of the FHB, and then rotate the probe 90° to obtain the cross-sectional image.
6. Peroneus longus and brevis (PER): Instruct the participants to lie in the supine position. Mark the fibular head and the inferior border of the lateral malleolus, and mark 50% of the line connecting the two points. Apply the coupling gel and place the probe to capture the thickness. To obtain the cross-sectional image, rotate the probe 90° at the point where the thickness measurement was taken.
7. Tibialis anterior (TA): Apply the coupling gel in front of the calf over 20% of the distance between the fibular head and the inferior border of the lateral malleolus. Place the probe longitudinally along the TA to obtain a thickness measurement.
  NOTE: Due to the scanning range of the probe, the CSA of the TA cannot be captured completely.
8. Image measurement: Look for the previously captured images on the right side of the screen. Use the trackball to move the cursor, select one image, and click on the Set button. Then, click on the Measure button. The measurement items appear on the left side of the screen.
  1. Thickness: Use the trackball to move the cursor, select the distance measurement, and click on the Set button. Mark the two points of the thickest part of the muscle in the image (Figure 1 and Figure 2). Record the distance for the thickness.
  2. Cross-sectional area (CSA): Use the trackball to move the cursor to trace the periphery of the muscle in the image. After tracing the cross-section of the entire muscle, click on the Set button (Figure 1 and Figure 2). Record the area for the CSA.
Muscle strength
1. Insert dynamometer Bluetooth stick into the USB interface of the computer. Open the dynamometer and FET Data Collection Software and click on the Start Gauge button to wait for automatic pairing.
2. Toe flexion strength test (FT1)
  1. Instruct the participant to sit in a chair with 90° flexion of the knee and ankle joint. Fix the dynamometer to the front side of the wooden frame. Connect the great toe to the dynamometer by carabiner (Figure 3B).
    NOTE: Adjust the appropriate bars to avoid pain during the test.
  2. Interchange the panels behind the foot to ensure that the heel to the head of the first metatarsal is supported while still allowing for unimpaired toe flexion. Adjust the carabiner so that the toe produces a steady baseline force, and then click on the Reset button to zero out the dynamometer.
  3. Click on the Start Gauge button in the software. Instruct the participant to remain stable until instructed to flex the big toe, pull as hard as possible for 3 s, and then relax the grip. Click on the Stop Gauge button, and save the data collected.
3. Toe flexion strength test (FT2-3 and FT2-5)
  1. Use the T-shaped metal bars to attach to the dynamometer. Instruct the participant to flex the 2nd-3rd toes or 2nd-5th toes. Perform a similar test procedure as the FT1 test (Figure 3C,D).
4. Doming test
  1. Place the dynamometer against the scaphoid tubercle. Instruct the participant to slide the forefoot toward the heel or raise the arch as much as possible without lifting or curling the toes, which would result in "shortening" of the foot and a raised medial longitudinal arch (Figure 3A).
  2. Then, ask the participant to do maximum voluntary contraction for 3 s. Perform data collection like previous toe flexion tests (steps 2.2.2 and 2.2.3).
    NOTE: Record three successful trials for the data process and provide sufficient rest time between trials to avoid fatigue.
5. Open the program software processing window and import the CSV files of the original strength data.
  1. Toe flexion force (FT1, FT2-3, FT2-5): Click on the Run button, select the Automatic Calculation option in the calculation list, and then click on the Calculation button. The software will actively calculate the peak strength of the toe grip (Figure 4).
  2. Doming force data: Import the original data into the software and click on the Run button. Select the Manual Calculation option in the calculation list. Then, drag the movable 0.5 s window manually, where the force curve is in the shape of a plateau, and the software will automatically calculate the average force in the window (Figure 5).

Figure 1: Representative ultrasound images of three intrinsic muscles. (A) Thickness Image of the abductor hallucis; (B) cross-sectional area of the abductor hallucis; (C) thickness image of the flexor digitorum brevis; (D) cross-sectional area of the flexor digitorum brevis; (E) thickness image of the quadratus plantae; and (F) cross-sectional area of the quadratus plantae. Please click here to view a larger version of this figure.

Figure 2: Representative ultrasound images of three extrinsic muscles. (A) Thickness image of the flexor hallucis brevis; (B) cross-sectional area of the flexor hallucis brevis; (C) thickness image of peroneus longus and brevis muscles; (D) cross-sectional area of peroneus longus and brevis muscles; and (E) thickness image of the tibialis anterior. Please click here to view a larger version of this figure.

Figure 3: Foot muscle strength test. (A) Doming test; (B) toe flexion strength test (FT1); (C) toe flexion strength test (FT2-3); (D) toe flexion strength test (FT2-5). Please click here to view a larger version of this figure.

Figure 4: Representative toe flexion strength plot. The peak force of toe flexion is calculated as the average value of six data points around the selected peak point. In the custom software, it is programmed that 10 points, including peak force remain relatively stable to avoid false peaks, which means that the remaining nine points do not exceed ±0.5 of the peak value. Please click here to view a larger version of this figure.

Figure 5: Representative doming strength plot. The force of maximum voluntary contraction is calculated for the doming strength. A movable 0.5 s window is present to determine where the force curve is in the shape of a plateau, which could be dragged manually. The strength of doming is programmed to calculate the average value of the selection window (0.5 ms). Please click here to view a larger version of this figure.

3. Passive subsystem

NOTE: The ND and foot posture index-6 (FPI-6) tests were applied to evaluate the foot structure (passive subsystem).

Navicular drop (ND) test
1. Assemble the height vernier caliper with the base, fixture block, and scribing claw. To specify the navicular tuberosity, extend the scribing claw through a stick. Place the height vernier caliper on the horizontal platform.
  NOTE: The ND test is performed on the same horizontal platform.
2. Instruct the participants to sit on a height-adjustable chair and turn sideways to allow visualization of the medial longitudinal arch. Palpate the navicular tuberosity and mark its location. Instruct the participants to sit in a position where the knee, hip, and ankle joints make a 90° angle.
3. Palpate the medial and lateral aspects of the participant's talus head. Supinate and pronate the subtalar joint until the medial and lateral sides of the talus are equally positioned.
4. Align the head of the scribing claw with the marked navicular tuberosity. Read and record the height at this non-weight-bearing position (height 1).
5. Instruct the participants to stand and keep the normal, bilateral, weight-bearing stance. Consistently, record the height (height 2).
6. Define the vertical movement of the navicular tuberosity (i.e., height 1-height 2) in the sagittal plane as ND.
  NOTE: In the process of the ND test, the participants must keep straight and look straight ahead.
Foot posture index-6 (FPI-6)
1. Perform the FPI-6 test on the horizontal platform as in the ND test (step 3.1.1).
2. Instruct the participants to take several steps, marching on the spot, and then stand in their relaxed stance position with double limb support. Inform them to stand still for approximately 2 min during the assessment.
3. Palpate the talar head and rate its position on the lateral and medial sides.
4. Palpate the lateral malleolar and score the supra- and infra-lateral malleolar curvature.
5. Observe the calcaneal frontal plane position and score the angle between the posterior aspect of the calcaneus and the long axis of the foot.
6. Palate the talonavicular joint (TNJ) and score the bulge or concave in this area.
7. Palate and observe the curve of the medial longitudinal arch and score its height and congruence.
8. Observe the forefoot directly behind and in line with the long axis of the heel and score the relative position of the forefoot on the rearfoot (abduction/adduction).
  NOTE: In this test, each item is scored as -2, -1, 0, 1, and 2 (see Supplementary File 1).

4. Neural subsystem

NOTE: In the assessment of the neural subsystem, the plantar light touch threshold, and a two-point discriminator (TPD) were applied to evaluate the plantar sensitivity.

Plantar light touch threshold
1. Prepare Semmes-Weinstein monofilament (SWM) kit, consisting of 20 pieces. Each SWM kit has an index number ranging from 1.65 to 6.65 (1.65, 2.36, 2.44, 2.83, 3.22, 3.61, 3.84, 4.08, 4.17, 4.31, 4.56, 4.74, 4.93, 5.07, 5.18, 5.46, 5.88, 6.10, 6.45, and 6.65), which is related to a calibrated breaking force (i.e., index 1.65 is the equivalent of 0.008 g of force).
  NOTE: The higher the index value, the stiffer and harder it is to bend.
2. Mark the test regions in the plantar sole, including the first toe (T1), first metatarsal head (MT1), third metatarsal head (MT3), fifth metatarsal head (MT5), midfoot (M), and heel (H).
3. Apply 4.74 SWM to the participants' thenar eminences to feel the stimulus, which they will receive on the plantar sole in the formal test. Instruct participants to say "yes" and inform the examiner of the accurate site clearly and loudly every time the participants perceive the sensory stimulus of SWM at any tested sites.
  NOTE: Every marked region can be replaced by one specific number in the convenience of memory.
4. Place each participant in the prone position on a standard treatment table facing away from the examiner with the foot hanging on the edge of the table. Instruct them to close their eyes and wear headphones to avoid the assistance of vision and minimize distraction, respectively.
5. Apply SWM perpendicularly to the skin at the target region. Pressure is appropriate until the nylon SWM is bent to form a "C" shape. Then, hold it for 1 s before removal. 4.74 SWM is first applied over the marked region, and a 4-2-1 stepping algorithm is utilized to standardize the assessment²¹. Test six plantar regions at random.
  NOTE: Provide a few seconds for rest in the interval of trails in case of sensory disturbance between marked regions. The last detected SWM is regarded as the threshold for that site.
Two-point discriminator (TPD)
1. Prepare the two-point discriminator device. The adjustable device has different distances, ranging from 1 mm to 15 mm.
  NOTE: One side of the dial ranges from 1 mm to 8 mm, and revolving the dial to the other side ranges from 9 mm to 15 mm.
2. Mark the six test regions in the plantar sole, which are the same as those in the case of the plantar light touch threshold test (step 4.1.2).
3. To make participants familiar with the testing process, apply the two-point discriminator in the participants' tip of the middle finger. Inform them to say "one" if they perceived one point or "two" if they perceived two points.
  NOTE: The test position is the same as that in the plantar light touch threshold test. The participants should keep their eyes closed.
4. Start the test from the greatest distance (8 mm), and then decrease the width distance by 5 mm until the participants report one point. Move the device in 1 mm increments applying randomization of one or two points until the participants can consistently identify two points at a test width.
  NOTE: Three times of correctly identifying two-point touch out of five touches is defined as positive. The last two-point value is recorded as the TPD threshold value.

Representative Results

In this study, 84 participants were included for measurement. The young group included 42 university students with an average age of 22.4 ± 2.9 years and height of 1.60 ± 0.05 m. The elderly group included 42 community-dwelling elderly with an average age of 68.9 ± 3.3 years and height of 1.59 ± 0.05 m.

Representative active subsystem results
The morphology and strength of foot muscles are used to determine the function of the active subsystem. Muscle strength data is normalized by weight (N/kg). As shown in the Figure 6, compared with young participants, foot muscle strengths were lower in the elderly for all tests (doming, t₍₈₂₎ = -6.81, p < 0.001; FT1, t₍₈₂₎ = -7.48, p < 0.001; FT2-3, t ₍₈₂₎ = -5.51, p < 0.001; FT2-5, t₍₈₂₎ = -6.91, p < 0.001).

As for muscle morphology (Figure 7), there were significant thickness differences in most muscles except TA between two groups (AbH, t₍₈₂₎ = -4.59, p < 0.001; FDB, t₍₈₂₎ = -2.91, p < 0.001; QP, t₍₈₂₎ = -3.83, p < 0.001; FHB, t₍₈₂₎ = -5.57, p < 0.001; PER, t₍₈₂₎ = -3.033, p = 0.003; TA, t₍₈₂₎ = -1.52, p = 0.13). Moreover, there were significant differences in CSA between two groups (AbH, t₍₈₂₎ = -3.55, p < 0.001; FDB, t₍₈₂₎ = -2.66, p < 0.001; QP, t₍₈₂₎ = -4.09, p < 0.001; FHB, t₍₈₂₎ = -5.70, p < 0.001; PER, t₍₈₂₎ = -3.63, p < 0.001) (Figure 8).

Figure 6: Difference in foot muscle strength between groups. Asterisk denotes the significant difference between young and elderly groups. Please click here to view a larger version of this figure.

Figure 7: Difference in muscle thickness between groups. AbH, abductor hallucis; FDB, flexor digitorum brevis; QP, quadratus plantae; FHB, flexor hallucis brevis; PER, peroneus longus and brevis muscles; TA, tibialis anterior. Asterisk denotes the significant difference between young and elderly groups. Please click here to view a larger version of this figure.

Figure 8: Difference in muscle cross-sectional area between groups. CSA, cross-sectional area; AbH, abductor hallucis; FDB, flexor digitorum brevis; QP, quadratus plantae; FHB, flexor hallucis brevis; PER, peroneus longus and brevis muscles. Asterisk denotes the significant difference between young and elderly groups. Please click here to view a larger version of this figure.

Representative passive subsystem results
For the passive subsystem, the ND and FPI-6 tests were applied to evaluate the foot structure and posture. Compared with young participants, the ND distance and FPI-6 score were higher in the elderly (ND, t₍₈₂₎ = 4.01, p < 0.001; FPI-6, t ₍₈₂₎ = 2.80, p = 0.006) (Figure 9).

Figure 9: Difference in the outcomes of passive subsystem between groups. ND, navicular drop test; FPI-6, foot posture index-6. Asterisk denotes the significant difference between young and elderly groups. Please click here to view a larger version of this figure.

Representative neural subsystem results
In this study, the plantar light touch threshold and TPD are used to determine the sensitivity of plantar sensation. In total, six regions of foot are selected for both neural subsystem measurements, including the first toe (T1), the first metatarsal head (MT1), the third metatarsal head (MT3), the fifth metatarsal head (MT5), the midfoot (M), and the heel (H)³¹.

As shown in the Figure 10, compared with young participants, the plantar light touch thresholds of six regions were higher in the elderly (T1, t₍₈₂₎ = 8.12, p < 0.001; MT1, t₍₈₂₎ = 7.98, p < 0.001; MT3, t₍₈₂₎ = 4.07, p < 0.001; MT5, t₍₈₂₎ = 5.14, p < 0.001; M, t₍₈₂₎ = 5.76, p < 0.001; H, t₍₈₂₎ = 4.78, p < 0.001).

Figure 10: Difference in the plantar light touch threshold between groups. T1, the first toe; MT1, the first metatarsal head; MT3, the third metatarsal head; MT5, the fifth metatarsal head; M, the midfoot; H, the heel. Asterisk denotes the significant difference between young and elderly groups. Please click here to view a larger version of this figure.

As shown in the Figure 11, compared with young participants, the TPD of six regions were higher in the elderly (T1, t₍₈₂₎ = 7.58, p < 0.001; MT1, t₍₈₂₎ = 7.66, p < 0.001; MT3, t₍₈₂₎ = 7.93, p < 0.001; MT5, t₍₈₂₎ = 7.83, p < 0.001; M, t₍₈₂₎ = 5.36, p < 0.001; H, t₍₈₂₎ = 3.45, p < 0.001).

Figure 11: Difference in the two-point discrimination between groups. T1, the first toe; MT1, the first metatarsal head; MT3, the third metatarsal head; MT5, the fifth metatarsal head; M, the midfoot; H, the heel. Asterisk denotes the significant difference between young and elderly groups. Please click here to view a larger version of this figure.

Supplementary File. Please click here to download this File.

Discussion

The presented protocol is used to measure the characteristics of the foot in the elderly, which provides a comprehensive assessment to investigate foot core stability, including the passive, active, and neural subsystems. This new paradigm illuminates the foot function that interacts to stabilize the foot and sustain sensorimotor function in daily activities³³. In previous studies, the researchers paid more attention to exploring foot deformity; toe flexion strength; diminished plantar sensory; and other pathologic conditions, such as diabetes, peripheral neuropathy, and heel pain, in the elderly²¹^,³⁴^,³⁵^,³⁶. The function of intrinsic foot muscles and the interaction among the three subsystems were ignored in previous foot assessments. With increased attention to intrinsic foot muscles, several qualitative methods have been utilized in clinical practice, such as manual muscle testing, paper grip, and intrinsic positive tests⁷^,³⁷. However, these methods are limited as they focus on the contribution of the intrinsic muscles in producing toe flexion, rather than the function of the supporting arch, which is more important⁵.

As done in this protocol, examining each subsystem, i.e., via plantar light touch threshold and TPD for the neural subsystem, the ND and FPI-6 for the passive subsystem, as well as the strength of intrinsic and extrinsic foot muscles for the active subsystem, may provide insights to identify different avenues for the foot function at the view of a multifunctional foot system. As mentioned previously, these qualitative methods are easy to implement in clinical functional evaluation. However, the reliability, validity, and action quality during the process need to be clarified⁵.

In addition, regarding the passive and neural subsystems, many studies have been conducted to investigate the effect of aging on related characteristics, including plantar sensory sensitivity, and foot posture. It is widely accepted that the plantar sensory declines significantly in the elderly, and their foot morphology is more inclined to a pronation posture³⁸^,³⁹. As the functional evaluation, the foot muscle strength test is considered as a direct measurement of the active subsystem.

Due to the simultaneous involvement of intrinsic and extrinsic muscles, the strength of intrinsic muscles is difficult to isolate and assess in previous studies. Therefore, different strength assessments are applied to separate the contributions of the intrinsic and extrinsic foot muscles, including toe flexion and doming tests. The doming movement, known as short-foot training in clinical practice, is performed to quantify the strength of intrinsic muscles with a dynamometer. Its good reliability (ICCs, 0.816-0.985) has been clarified in a previous study²⁸. Using the same force measuring device in a fixed state, provides direct comparisons between intrinsic and extrinsic muscles, even between current and future data. Meanwhile, as the indirect measurement of intrinsic foot muscle, the muscle morphology (thickness and CSA) is determined by ultrasound, which has been applied in relevant foot studies⁴⁰^,⁴¹.

In the current study, the results showed a significant difference in the characteristics of the active subsystem between young and old groups, which is consistent with previous studies⁴¹^,⁴². As shown in Figure 6, compared with young adults, the elderly participants had about a 29% to 39% decrease in foot muscle strength (doming, FT1, FT2-3, and FT2-5). Similarly, there were significant intergroup differences in the foot muscle morphology (thickness and CSA) (Figure 7 and Figure 8).

The following steps in the protocol are critical in investigating the characteristics of the foot core system and are associated with accurate measurement. a) During the neural subsystem tests, the participants are instructed to respond clearly and loudly every time they perceive the sensory stimulation. Therefore, conduct these tests in a separate, quiet room to ensure accuracy and make sure that the participants have become familiar with the test. b) In the muscle morphology test, apply minimal pressure to the ultrasound probe to reduce soft tissue deformation. The test and image processing should be operated by the same assessor⁴³. c) Correct the alignment of the foot in the ND and FPI-6 tests for the correct measurement of foot posture. d) In the strength test, ensure the correct setup of the dynamometer and wooden fixing frame. Measure doming and toe flexion movement with good quality. e) Fatigue of plantar intrinsic foot muscles will increase the ND, and then further change the foot posture⁴⁴. Although no direct evidence has explored the association between foot muscle fatigue and plantar sensory, a previous study reported that the skin's sensory ability is reduced after inducing fatigue of the upper and lower extremities⁴⁵. Therefore, the strength test should be performed last, and the participants should be given time to rest between each trial to avoid cognitive loading and muscle fatigue.

Several limitations need to be considered when implementing measurement. First, considering the anatomical and biomechanical configuration of intrinsic foot muscles, it has been suspected that these muscles contributed to providing immediate sensory information via the sensory receptors, rather than producing large joint motions⁵. However, due to the technological limitation, there is currently no appropriate method to evaluate the sensory function of intrinsic foot muscles and its effect on foot function. Second, ultrasound is applied, rather than MRI, to determine the morphology, which is regarded as the gold standard method to quantify foot tissue⁴⁶. In future studies, MRI should be applied to gain more insights into the musculature of the foot. In addition, the lack of a corresponding multimodal approach is indeed a limitation of this study. Future studies will further explore the association of relevant factors with physical function outcomes in older adults.

As a direct interface between the body and the ground, the foot contributes to the collection of somatosensory information and adapts to different load conditions through the coordination between the controls of muscular activity and deformations of functional arch⁴⁷. Several characteristics of the foot core system are changed in individuals with a flat foot, plantar fasciitis, diabetes, and even healthy elderly individuals¹⁴^,²²^,⁴⁸^,⁴⁹. The foot core stability is also rooted in the functional interdependence of these three subsystems. Measuring the characteristics in one subsystem would not provide a complete view to evaluate the foot function.

This protocol is based on the composition of the foot core system, which could provide evidence for the scientific community. In clinical practice, this protocol will help to evaluate the effect of foot health-care programs and foot muscle rehabilitation for the treatment of foot conditions, such as flat foot, plantar fasciitis, and heel pain. As a segment in the lower extremity, the foot plays an important role in postural stability in most postures and dynamic activities. Therefore, it might provide insights into foot function in future research on disease nursing and neuromuscular control.

Declarações

The authors have nothing to disclose.

Acknowledgements

The authors acknowledge the funding of the Breeding Program of Shanghai Tenth People's Hospital (YNCR2C022).

Materials

Diagnostic Ultrasound System	Mindray	It is used in clinical ultrasonic diagnostic examination.
ergoFet dynamometer	ergoFet	It is an accurate, portable, push/pull force gauge, which is designed to be a stand-alone gauge for capturing individual force measurements under any job condition.
Height vernier caliper		It is an accurate measure tool for height.
LabVIEW		It is a customed program software for strength analysis.
Semmes-Weinstein monofilaments	Baseline	It consists of 20 pieces, and each SWM haves an index number ranging from 1.65 to 6.65, that is related with a calibrated breaking force.
Two-Point Discriminator	Touch Test	It is a set of two aluminum discs, each containing a series of prongs spaced between 1 to 15 mm apart.

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Lai, Z., Hu, X., Xu, L., Dong, K., Wang, L. Evaluating the Function of the Foot Core System in the Elderly. J. Vis. Exp. (181), e63479, doi:10.3791/63479 (2022).