神经导航引导下重复经颅磁刺激的失语
Summary
This study is designed to test the hypothesis that neuronavigational system-guided transcranial magnetic stimulation has higher accuracy for targeting the intended target as demonstrated by eliciting a greater degree of virtual aphasia in healthy subjects, measured by delay in reaction time to picture naming.
Abstract
重复经颅磁刺激（磁刺激）被广泛用于多种神经系统疾病，因为它已经获得了确认其潜在的治疗效果。大脑兴奋是经颅磁刺激非侵入性调制，经颅磁刺激的语言领域已经证明了它的治疗失语的潜在影响。在我们的协议中，我们的目标是通过使用neuronavigational TMS（NTMS），以及国际10-20脑电图系统为常规的TMS（CTMS）的F3抑制布洛德曼区域44和45人工诱导健康受试者虚拟失语。为了测量失语的程度，在反应时间到画面命名任务前和刺激后的变化进行测量，并比较在NTMS和CTMS之间的反应时间的延迟。两个TMS刺激方法准确性通过平均目标和实际刺激塔莱拉什坐标进行比较。刺激的一致性是通过从目标的误差范围内表现出来。这STU的目的DY是展示使用NTMS的，并描述相比，这些CTMS的NTMS的优点和局限性。
Introduction
重复经颅磁刺激（磁刺激）非侵入激活神经元回路中的中枢和外周神经系统。1磁刺激调制大脑兴奋2，并在几个精神病和神经性疾病的潜在治疗作用，如电机的弱点，失语，忽视，和疼痛3比运动皮层使用国际10-20脑电系统通常被确定的其他颅磁刺激，或通过测量特定外部的地标距离目标点。
然而，在尺寸，解剖学，和大脑皮质的形态学的个体间的差异不考虑，使得最佳目标定位有挑战性。3为磁刺激应用的另一个关键问题是在磁性线圈的位置和皮质区之间的偏差预期刺激。
光学跟踪导航神经外科有EXP相与它的应用程序涵盖包括rTMS治疗的电磁线圈的指导认知神经科学领域。该neuronavigational系统协助查明rTMS治疗的最佳目标结构。在对目标区域定位线圈4,5这样的分歧经常与采用脑电图10-20系统的传统方法时，这有望在神经导航克服。
这项研究办法表明诱导由neuronavigational的rTMS针对布罗卡区，采用个别解剖标测健康受试者虚拟失语的方法。虚拟失语在反应时间到图像命名变化方面的程度进行测量，并与从常规的刺激方法相比。神经导航引导方法具有用于递送磁脉冲到脑更高的精度，并且因此预计证明比传统方法更大的临床变化。此螺栓的目标y为引入刺激的更精确和有效的方法，患者的临床设置失语。
Protocol
Representative Results
Discussion
TMS无论是在临床实践和基础研究被广泛使用。10有价值的治疗作用是由磁刺激的生理影响，包括皮质兴奋与低频磁刺激治疗失语症的抑制神经调节作用所提供。神经处理或虚拟的11瞬态中断通过磁刺激诱 导损毁可以改变行为表现。12然而，磁刺激的期望的效果，可以稀释或甚至不具有错位的目标上的线圈发生。误瞄准原本预定目标和实际的刺激皮层区域之间可以发生?…
Disclosures
The authors have nothing to disclose.
Acknowledgements
这项研究是由来自韩国医疗技术的R＆D项目，卫生部和福利，韩国的赠款（A101901）的支持。我们感谢吉扬李医生在整个过程提供技术援助。
Materials
| Medtronic MagPro X100 | MagVenture | 9016E0711 | |
| MCF-B65 Butterfly coil | MagVenture | 9016E042 | |
| Brainsight TMS Navigation | Rogue Research | KITBSF1003 |
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