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Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

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3,021 Views

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08:16 min

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September 21, 2021

DOI:

10.3791/63081-v

DOI:
10.3791/63081-v

•

08:16 min
September 21, 2021

•

3 Views
, , , , , ,
1Institute for Food Nutrition and Human Health, School of Food Science and Engineering,South China University of Technology, 2School of Bioscience and Bioengineering,Hebei University of Economics and Business, 3Perfect Life & Health Institute

Summary

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Here, we present a protocol to assess the neuroprotective activities of test compounds in Caenorhabditis elegans, including polyglutamine aggregation, neuronal death, and chemoavoidance behavior, as well as an exemplary integration of multiple phenotypes.

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Wang, Q., Zhang, J., Jiang, Y., Xiao, Y., Li, X., Mao, X., Huang, Z. Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity. J. Vis. Exp. (175), e63081, doi:10.3791/63081 (2021).

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