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An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats
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Immunology and Infection
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JoVE Journal Immunology and Infection
An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

English

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7,377 Views

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09:25 min

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May 08, 2020

DOI:

10.3791/60956-v

DOI:
10.3791/60956-v

•

09:25 min
May 08, 2020

•

2 Views
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1Regenerative Medicine and Experimental Surgery, Department of General, Visceral and Transplant Surgery,Hannover Medical School

Summary

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We describe a model of heterotopic abdominal heart transplantation in rats, implying modifications of current strategies, which lead to a simplified surgical approach. Additionally, we describe a novel rejection model by in-ear injection of vital cardiac muscle cells, allowing further transplant immunological analyses in rats.

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Cite this Article

Weigle, C. A., Lieke, T., Vondran, F. W. R., Timrott, K., Klempnauer, J., Beetz, O. An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats. J. Vis. Exp. (159), e60956, doi:10.3791/60956 (2020).

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