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Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

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6,943 Views

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11:03 min

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February 10, 2020

DOI:

10.3791/60638-v

DOI:
10.3791/60638-v

•

11:03 min
February 10, 2020

•

11 Views
, , , , , , ,
1Department of Basic Sciences,Kansas City University of Medicine and Biosciences, 2Rice University School of Medicine, 3University of Kansas Medical Center

Summary

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Blood-based biomarkers for neurodegenerative diseases are essential for implementing large-scale clinical studies. A reliable and validated blood test should require a small sample volume as well as be a less invasive sampling method, affordable, and reproducible. This paper demonstrates that high-throughput capillary electrophoresis immunoassay satisfies criteria for potential biomarker development.

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Capillary ElectrophoresisImmunoassayBiomarkersAmyotrophic Lateral SclerosisALSHuman PlateletsHigh-throughputBlood-based BiomarkerClinical TrialsProtein ProfilingDrug Monitoring

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Sage, J. M., Hall, L., McVey, A., Barohn, R. J., Statland, J. M., Jawdat, O., Dimachkie, M. M., Agbas, A. Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets. J. Vis. Exp. (156), e60638, doi:10.3791/60638 (2020).

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