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Immunology and Infection
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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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Immunology and Infection
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JoVE Journal Immunology and Infection
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

English

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2,771 Views

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11:36 min

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May 29, 2020

DOI:

10.3791/59174-v

DOI:
10.3791/59174-v

•

11:36 min
May 29, 2020

•

5 Views
, , , ,
1Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University, 2Department of Pediatrics and Pathology,Johns Hopkins University

Summary

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We describe an in vivo immunization, translational hepatitis model in BALB/c mice that can be utilized to study the pathogenesis of drug-induced autoimmune hepatitis including sex differences seen in this disease. We will describe how this model demonstrates reproducible analyses using in vivo and in vitro experimental techniques.

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Thomas, D., Wu, T. Y., Cottagiri, M., Nyandjo, M., Njoku, D. B. Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms. J. Vis. Exp. (159), e59174, doi:10.3791/59174 (2020).

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