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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
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Medicine
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JoVE Journal Medicine
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution

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11,420 Views

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04:14 min

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April 16, 2019

DOI:

10.3791/59130-v

DOI:
10.3791/59130-v

•

04:14 min
April 16, 2019

•

6 Views
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1Cardiovascular, Renal and Metabolic Diseases,MedImmune, 2Laboratory Animal Resources,MedImmune

Summary

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In clinical settings, a liver biopsy is used to assess stages of non-alcoholic steatohepatitis (steatosis, inflammation, hepatocyte ballooning, and fibrosis). Here, we illustrate a survivable liver biopsy in mice which can be used for histological analyses to enable assessment of therapeutic agents in a manner more aligned with clinical trials.

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Oldham, S., Rivera, C., Boland, M. L., Trevaskis, J. L. Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution. J. Vis. Exp. (146), e59130, doi:10.3791/59130 (2019).

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