Here we describe a method to inflict closed head traumatic brain injury (TBI) in Drosophila. This method provides a gateway to investigate the cellular and molecular mechanisms that underlie TBI pathologies using the vast array of experimental tools and techniques available for flies.
Katzenberger, R. J., Loewen, C. A., Bockstruck, R. T., Woods, M. A., Ganetzky, B., Wassarman, D. A. A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila. J. Vis. Exp. (100), e52905, doi:10.3791/52905 (2015).