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Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
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Developmental Biology
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JoVE Journal Developmental Biology
Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

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10,984 Views

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09:45 min

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March 31, 2015

DOI:

10.3791/52567-v

DOI:
10.3791/52567-v

•

09:45 min
March 31, 2015

•

1 Views
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1Department of Molecular Pharmacology & Experimental Therapeutics,Mayo Clinic College of Medicine, Center for Individualized Medicine, 2Tufts University School of Medicine, 3Department of Biochemistry and Molecular Biology,Mayo Clinic

Summary

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The goal of this study is to demonstrate how the mosaic transgenesis strategy can be used in zebrafish to rapidly and efficiently assess the relative contributions of multiple oncogenes in tumor initiation and progression in vivo.

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Cite this Article

Ung, C. Y., Guo, F., Zhang, X., Zhu, Z., Zhu, S. Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis. J. Vis. Exp. (97), e52567, doi:10.3791/52567 (2015).

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