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Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

English

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28,277 Views

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15:33 min

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October 29, 2013

DOI:

10.3791/50890-v

DOI:
10.3791/50890-v

•

15:33 min
October 29, 2013

•

20 Views
, ,
1Department of Biomedical Engineering,University of Rochester, 2Department of Chemical Engineering,University of Rochester, 3Center for Musculoskeletal Research,University of Rochester Medical Center

Summary

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This video will illustrate a rapid, efficient method to methacrylate poly(ethylene glycol), enabling chain polymerizations and hydrogel synthesis. It will demonstrate how to similarly introduce methacrylamide functionalities into peptides, detail common analytical methods to assess functionalization efficiency, provide suggestions for troubleshooting and advanced modifications, and demonstrate typical hydrogel characterization techniques.

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Cite this Article

Van Hove, A. H., Wilson, B. D., Benoit, D. S. W. Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation. J. Vis. Exp. (80), e50890, doi:10.3791/50890 (2013).

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