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December 07, 2011
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A longitudinal examination of bone loss in the femurs and tibiae of adult mice was performed following spinal cord injury using sequential low-dose X-ray scans. Tibia bone loss was detected throughout the study, while bone loss in the femur was not detected until 40 days post injury.
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Longitudinal EvaluationMouseHind LimbBone LossSpinal Cord InjuryIn Vivo MethodologyOsteoporosisFracturesSensory FunctionBone Mineral DensityBone Mineral ContentMechanical DisuseNeuronal SignalingHormonal ChangesRodent ModelsGeneration Of New TherapiesNull And Transgenic MiceMinimally-invasiveReliableReproducibleQuantifiable MethodsDiagnosisTreatment MethodsPrevention Of SCI-induced Osteoporosis
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McManus, M. M., Grill, R. J. Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology. J. Vis. Exp. (58), e3246, doi:10.3791/3246 (2011).
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