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The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
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The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice

The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice

English

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61,930 Views

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07:44 min

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August 18, 2011

DOI:

10.3791/3092-v

DOI:
10.3791/3092-v

•

07:44 min
August 18, 2011

•

30 Views
, , ,
1The Lundbeck Foundation Research Center MIND, Department of Biomedicine,Aarhus University, 2Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences,University of Copenhagen

Summary

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The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.

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Richner, M., Bjerrum, O. J., Nykjaer, A., Vaegter, C. B. The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice. J. Vis. Exp. (54), e3092, doi:10.3791/3092 (2011).

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