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July 25, 2011
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A comprehensive overview of the techniques involved in generating a mouse model of oral cancer and quantitative monitoring of tumor invasion within the tongue through multi-photon microscopy of labeled cells is presented. This system can serve as a useful platform for the molecular assessment and drug efficacy of anti-invasive compounds.
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Gatesman Ammer, A., Hayes, K. E., Martin, K. H., Zhang, L., Spirou, G. A., Weed, S. A. Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma. J. Vis. Exp. (53), e2941, doi:10.3791/2941 (2011).
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