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Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

English

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19,842 Views

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16:13 min

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June 13, 2011

DOI:

10.3791/2910-v

DOI:
10.3791/2910-v

•

16:13 min
June 13, 2011

•

2 Views
, , ,
1Department of Neurology and Committee on Neurobiology,The University of Chicago Medical Center, 2Department of Neurology,The University of Chicago Medical Center

Summary

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Migraine and its transformation to chronic migraine are immense healthcare burdens in need of improved treatment options. We seek to define how neural immune signaling modulates the susceptibility to migraine, modeled in vitro using spreading depression in hippocampal slice cultures, as a means to develop novel therapeutic targets.

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Cite this Article

Pusic, A. D., Grinberg, Y. Y., Mitchell, H. M., Kraig, R. P. Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro. J. Vis. Exp. (52), e2910, doi:10.3791/2910 (2011).

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