9.2:
Hypertension and Regulation of Blood Pressure
Hypertension, or high blood pressure, is a common cardiovascular disease with sustained readings at or above 130/80 mm Hg.
It increases the risks of heart, brain, and kidney damage.
It can be categorized as primary, with no specific cause, or secondary, stemming from a known disease or condition, such as Cushing's disease or thyroid dysfunction.
Factors contributing to hypertension include genetics, poor diet, obesity, excessive alcohol consumption, and tobacco use.
Hypertension management involves reducing arterial blood pressure by regulating the cardiac output, the arterioles' resistance, the venules' capacitance, and the renal response in blood volume control.
The anatomic sites the heart, kidneys, and arteries work together through baroreflex and humoral mechanisms.
Baroreflexes quickly detect arterial pressure changes, adjusting heart rate and vascular resistance.
The humoral mechanism involves the release of hormones and other substances, such as angiotensin II, aldosterone, and vasopressin, to help regulate blood pressure.
9.2:
Hypertension and Regulation of Blood Pressure
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or already occurred.
Primary hypertension has no identifiable cause, while secondary hypertension has a specific etiology. Elevated blood pressure is typically linked with increased resistance to blood flow through arterioles, with normal cardiac output. It is believed to be caused by multiple abnormalities, with contributory factors including genetic influences, psychological stress, and dietary factors such as high salt intake and low potassium or calcium intake.
Physiologically, blood pressure is regulated by the cardiac output and peripheral vascular resistance. This regulation occurs at the arterioles, postcapillary venules, heart, and kidneys. Baroreflexes, mediated by autonomic nerves, alongside humoral mechanisms, coordinate function at these points to maintain normal blood pressure.
Baroreflexes are accountable for rapid adjustments in blood pressure, reacting to events that lower arterial pressure. The kidney's control of blood volume is pivotal for long-term blood pressure control. When renal perfusion pressure reduces, it triggers the reabsorption of salt and water and renin production, which initiates the renin-angiotensin-aldosterone system (RAAS). It leads to the synthesis of angiotensin II, causing direct vasoconstriction and stimulating aldosterone production. Aldosterone increases renal sodium absorption and intravascular blood volume. Vasopressin also helps maintain blood pressure through its ability to regulate water reabsorption by the kidney.