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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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発生生物学
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JoVE Journal 発生生物学
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

2,882 Views

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11:02 min

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April 13, 2022

DOI:

10.3791/63671-v

DOI:
10.3791/63671-v

•

11:02 min
April 13, 2022

•

5 Views
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1Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, Leuven Stem Cell Institute,KU Leuven (University of Leuven), 2Biomedical Research Institute (BIOMED),UHasselt, Hasselt University

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We present a protocol to develop epithelial organoid cultures starting from human tooth. The organoids are robustly expandable and recapitulate the tooth's epithelial stem cells, including their ameloblast differentiation capacity. The unique organoid model provides a promising tool to study human dental (stem cell) biology with perspectives for tooth-regenerative approaches.

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Cite this Article

Hemeryck, L., Lambrichts, I., Bronckaers, A., Vankelecom, H. Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy. J. Vis. Exp. (182), e63671, doi:10.3791/63671 (2022).

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