The footpad inoculation model is a valuable tool for characterizing viral-induced neuroinflammatory responses in vivo. In particular, it provides a clear assessment of viral kinetics and associated immunopathological processes initiated in the peripheral nervous system.
Laval, K., Maturana, C. J., Enquist, L. W. Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses. J. Vis. Exp. (160), e61121, doi:10.3791/61121 (2020).