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יעיל הקמת פיגומים, כמו סמים Bispirocyclic דרך Organocatalytic Cycloadditions של α-Imino וγ-Lactones ו- Alkylidene Pyrazolones
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February 07, 2019
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Enantiomerically מועשר bispiro [γ-ביוטרולקטון-pyrrolidin-4, 4'-pyrazolone] שלדים הם בצורה א-סימטרית מסונתז דרך תגובה 1, 3-dipolar cycloaddition organocatalytic פשוטה.
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Keyword Extraction:Drug-like Bispirocyclic ScaffoldsOrganocatalytic Cycloadditionsα-imino γ-lactonesAlkylidene PyrazolonesBipolar CycloadditionBispirocyclic CompoundsNatural ProductsBiological ActivitiesChiral Spiral CentersHigh YieldsStereoselectivityPyrazoloneHydrazineEthyl Acetoacetateα-arylidiene PyrazolinoneBenzaldehydeMagnesium OxideAcetonitrile
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Zhou, Y., Chen, N., Cheng, Y., Cai, X. Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones. J. Vis. Exp. (144), e59155, doi:10.3791/59155 (2019).
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