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在小鼠中纳入可存活的肝脏活检程序评估非酒精性脂肪性肝炎 (NASH) 的解决方法
JoVE Journal
医学
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JoVE Journal 医学
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
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在小鼠中纳入可存活的肝脏活检程序评估非酒精性脂肪性肝炎 (NASH) 的解决方法

11,420 Views

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04:14 min

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April 16, 2019

DOI:

10.3791/59130-v

DOI:
10.3791/59130-v

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04:14 min
April 16, 2019

•

6 Views
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1Cardiovascular, Renal and Metabolic Diseases,MedImmune, 2Laboratory Animal Resources,MedImmune

概要

Automatically generated

在临床环境中, 肝脏活检用于评估非酒精性脂肪性肝炎 (脂肪变性、炎症、肝细胞膨胀和纤维化) 的各个阶段。在这里, 我们说明了小鼠的可存活肝活检, 可用于组织学分析, 以便能够以更符合临床试验的方式评估治疗药物。

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Oldham, S., Rivera, C., Boland, M. L., Trevaskis, J. L. Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution. J. Vis. Exp. (146), e59130, doi:10.3791/59130 (2019).

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