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苷 2 ', 3 ' -二醇酯对双糖苷合成的选择性O-糖基化
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2′,3′-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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苷 2 ', 3 ' -二醇酯对双糖苷合成的选择性O-糖基化

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08:46 min

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July 26, 2018

DOI:

10.3791/57897-v

DOI:
10.3791/57897-v

•

08:46 min
July 26, 2018

•

2 Views
, , ,
1製薬科学部,Tokyo University of Science, 2Imaging Frontier Center,Tokyo University of Science

概要

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在这里, 我们提出了合成双糖苷的协议, 选择性O-糖基化的 ribonucleosides通过临时保护其 2 ', 3 '-二醇的基团利用循环硼酸酯。该方法适用于几种不受保护的苷, 如腺苷、鸟嘌呤、胞苷、苷、5-methyluridine 和 5-fluorouridine, 给予相应的双糖苷。

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Regioselective O-glycosylationNucleosideBoronic EsterDisaccharide NucleosideTemporary Diol ProtectionDrug DiscoveryGlycosylationUnprotected NucleosideReaction OptimizationSynthesis

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Someya, H., Itoh, T., Kato, M., Aoki, S. Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides. J. Vis. Exp. (137), e57897, doi:10.3791/57897 (2018).

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