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Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules
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発生生物学
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JoVE Journal 発生生物学
Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules

Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules

13,185 Views

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13:35 min

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June 26, 2017

DOI:

10.3791/55203-v

DOI:
10.3791/55203-v

•

13:35 min
June 26, 2017

•

3 Views
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1UMR 1188 Diabète athérothombose Thérapie Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, France,Université de La Réunion, INSERM, 2RIPA (Radiochimie et Imagerie du Petit Animal),Cyclotron de la Réunion Océan Indien CYROI, 3CHU de La Réunion

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This work describes methods to establish acute and chronic hyperglycemia models in zebrafish. The aim is to investigate the impact of hyperglycemia on physiological processes, such as constitutive and injury-induced neurogenesis. The work also highlights the use of zebrafish to follow radiolabeled molecules (here, [18F]-FDG) using PET/CT.

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ZebrafishHyperglycemiaNeurogenesisBiodistributionRadiolabeled MoleculesAcute HyperglycemiaChronic HyperglycemiaDiabetesBrain RemodelingIschemic StrokeAnimal ModelIntraperitoneal InjectionBlood Glucose Measurement

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Dorsemans, A., Lefebvre d'Hellencourt, C., Ait-Arsa, I., Jestin, E., Meilhac, O., Diotel, N. Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules. J. Vis. Exp. (124), e55203, doi:10.3791/55203 (2017).

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