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기능 유전체학에게 검사를 활용하여 암 세포 회전 타원체 문화에 잠재적으로 소설 약 표적을 식별하는
JoVE Journal
がん研究
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JoVE Journal がん研究
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

기능 유전체학에게 검사를 활용하여 암 세포 회전 타원체 문화에 잠재적으로 소설 약 표적을 식별하는

DOI:

07:48 min

December 26, 2016

, , , , , , , ,

  • 00:05標題
  • 01:17Reverse Transfection of BT474 Cells
  • 03:51Automated Image Acquisition
  • 05:23Results: Functional Genomic Investigation of BT474 Spheroids Uncovers Oncogenic Dependencies
  • 07:02Conclusion

概要

自動翻訳

Identifying novel drug targets that transition from pre-clinical testing to human trials is a scientific priority. To that end, here we describe a functional genomics approach for examining the impact of gene depletion on cancer cell line spheroids, which more appropriately model human cancers in vivo.

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