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August 16, 2016
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Isolated working heart models can be used to measure the effect of loading conditions, heart rate, and medications on myocardial performance and oxygen consumption. We describe methods for preparation of a rodent left heart working model that permits study of systolic and diastolic performance and oxygen consumption under various conditions.
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RodentWorking Heart ModelMyocardial PerformanceOxygen ConsumptionCardiovascular PhysiologyVentricular LoadingContractilityDissectionIsolationAortaLeft AtriumPulmonary VeinsSedationAnalgesiaAnticoagulationHeparinPeritoneal CavityDiaphragmThoraxPericardiumPleuraInferior Vena CavaAortaEsophagusTracheaBrachiocephalic ArteriesVeinsThymusLangendorff ApparatusAortic ValveRight Subclavian Artery
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DeWitt, E. S., Black, K. J., Kheir, J. N. Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption. J. Vis. Exp. (114), e54149, doi:10.3791/54149 (2016).
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