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持続的な障害と皮質虚血を研究するために高齢ラットにおける一般的な頸動脈閉塞と永久遠位中大脳の実行
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February 23, 2016
DOI:
1Wolfson Centre for Age-Related Diseases,King’s College London, University of London, 2Department of Neuroimaging, James Black Centre, Institute of Psychiatry,King’s College London, University of London, 3Institute of Neuroscience and Psychology, Wellcome Surgical Institute, College of Medical, Veterinary and Life Sciences,University of Glasgow, Glasgow, 4Research Service,Edward Hines Jr. VA Hospital, 5Neurology Service,Edward Hines Jr. VA Hospital, 6Department of Molecular Pharmacology and Therapeutics, Neuroscience Research Institute,Loyola University Chicago, 7Department of Oncology, The Gray Institute for Radiation, Oncology and Biology,University of Oxford
概要
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ここでは、大規模な皮質梗塞と持続的な赤字を生成するために、頸動脈の同時閉塞と高齢雌ラットの永久遠位中大脳動脈閉塞を生成するためのプロトコルを提示します。私たちは、脳卒中後24時間および8週目に構造的MRIを用いて、病変の大きさの確認を示します。
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Wayman, C., Duricki, D. A., Roy, L. A., Haenzi, B., Tsai, S., Kartje, G., Beech, J. S., Cash, D., Moon, L. Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability. J. Vis. Exp. (108), e53106, doi:10.3791/53106 (2016).
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