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ניסוי הגלאוקומה נגרמת על ידי הזרקת Ocular של מיקרוסכמות מגנטית
JoVE Journal
医学
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JoVE Journal 医学
Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres
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ניסוי הגלאוקומה נגרמת על ידי הזרקת Ocular של מיקרוסכמות מגנטית

16,644 Views

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06:35 min

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February 02, 2015

DOI:

10.3791/52400-v

DOI:
10.3791/52400-v

•

06:35 min
February 02, 2015

•

6 Views
, , , , , , ,
1Ocular Biology and Therapeutics,University College London Institute of Ophthalmology, 2University College London Institue of Ophthalmology, 3Moorfields Eye Hospital, 4NIHR Biomedical Research Centre,Moorfields Eye Hospital, 5Schepens Eye Research Institute,Harvard Medical School, 6Hoffman-La Roche

概要

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We present a method for inducing elevated intraocular pressure (IOP), by injecting magnetic microspheres into the rat eye, to model glaucoma. This leads to strong pressure rises, and extensive neuronal death. This protocol is easy to perform, does not require repeat injections, and produces stable long-lasting IOP rises.

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GlaucomaIntraocular PressureMagnetic MicrospheresOcular InjectionAnimal ModelTrabecular MeshworkGanglion Cell LayerOptic Nerve Pathology

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Cite this Article

Bunker, S., Holeniewska, J., Vijay, S., Dahlmann-Noor, A., Khaw, P., Ng, Y., Shima, D., Foxton, R. Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres. J. Vis. Exp. (96), e52400, doi:10.3791/52400 (2015).

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