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Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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医学
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JoVE Journal 医学
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

DOI:
10.3791/52383-v

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09:01 min

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March 10, 2015

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, ,
1The Walter and Eliza Hall Institute for Medical Research, 2The Department of Medical Biology,University of Melbourne, 3Olivia Newton-John Cancer Research Institute

章

  • 00:05標題
  • 02:02Pre-clinical Trial in an Epithelial Damage and Acute Colitis Model
  • 04:32Endoscope Examinations
  • 07:24Results: Acute DSS-induced Mucosal Damage
  • 08:25Conclusion

概要

自動翻訳

自動翻訳

We describe methods for longitudinal monitoring of the efficacy of therapeutics for the treatment of colonic pathologies in mice using a rigid endoscope. This protocol can be readily used for the characterization of the therapeutic response of an individual tumor in live mice and also for monitoring potential disease relapse.

タグ

Non-invasive AssessmentTherapeutic EfficacyIntestinal PathologiesEndoscopic ImagingLive MiceAnimal ModelsInflammatory Bowel DiseaseColorectal CancerPre-clinical StudiesAcute Mucosal DamageChronic ColitisColitis-associated Colon CancerSporadic Colorectal CancerSerial Endoscopic ExaminationTherapeutic ResponseHealth Monitoring

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