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Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
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February 23, 2015
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Gonadal hormones such as estrogen modulate memory formation in a number of experimental paradigms including fear extinction memory. This protocol describes a set of methods for investigating the influence of gonadal hormones specifically during extinction in naturally cycling females, including estrous cycle monitoring and exogenous estrogen administration.
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Maeng, L. Y., Cover, K. K., Landau, A. J., Milad, M. R., Lebron-Milad, K. Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats. J. Vis. Exp. (96), e52202, doi:10.3791/52202 (2015).
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