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粒细胞相关的自身抗体引起的皮肤起泡
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免疫学と感染
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JoVE Journal 免疫学と感染
Granulocyte-dependent Autoantibody-induced Skin Blistering
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粒细胞相关的自身抗体引起的皮肤起泡

10,386 Views

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12:23 min

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October 12, 2012

DOI:

10.3791/4250-v

DOI:
10.3791/4250-v

•

12:23 min
October 12, 2012

•

4 Views
, ,
1皮膚学部,University of Freiburg , 2Kepler High School Freiburg, 3Centre for Biological Signalling Studies (BIOSS),University of Freiburg

概要

Automatically generated

在动物模型中描述在我们目前的工作中，纯化的IgG抗体对拉伸的200个氨基酸（氨基酸757-967）的胶原纤维VII反复被注入到小鼠体内，再现起泡表型以及直方和免疫病理学特征对人体acquisita大疱性表皮松解症（EBA）<sup> 1</sup>。

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Cite this Article

Csorba, K., Sitaru, S., Sitaru, C. Granulocyte-dependent Autoantibody-induced Skin Blistering. J. Vis. Exp. (68), e4250, doi:10.3791/4250 (2012).

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