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Predicting Amino Acid Preferences of Protein-Protein Binding Interfaces

Predicting Amino Acid Preferences of Protein-Protein Binding Interfaces

January 26, 2024

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1Facultad de Ciencias y Tecnología,Universidad Tecnológica de Panamá (UTP), 2Centro de Biología Molecular y Celular de Enfermedades,Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT AIP), 3Sistema Nacional de Investigación de Panamá (SNI)

概要

We describe a methodology based on sequence diversification to estimate the amino acid preferences of multispecific binding sites in protein-protein interactions (PPIs). In this strategy, thousands of potential peptide ligands are generated and screened in silico, thus overcoming some limitations of available experimental methods.

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