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Selective Gene Silencing in the Choroid Plexus

Selective Gene Silencing in the Choroid Plexus

June 16, 2023

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research

ChP Specific Knockdown of A2ARs with AAV2/5-shRNA and Cre/LoxP System

Yuwen Yang*¹, Chenxing Qi*¹, Lanxin Hu¹, Cheng Zheng¹, Xuhang Li¹, Wu Zheng¹, Yiyun Weng², Haiyan Lin^3,4

¹State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital,Wenzhou Medical University, ²Department of Neurology,the First Affiliated Hospital of Wenzhou Medical University, ³Rehabilitation Medicine Center,The Second Affiliated Hospital of Wenzhou Medical University, ⁴Integrative & Optimized Medicine Research Center, China-USA Institute for Acupuncture and Rehabilitation,Wenzhou Medical University

概要

Here, we describe a method to selectively alter gene expressions in the choroid plexus while avoiding any impact in other brain areas.

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