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Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
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March 31, 2023
DOI:
1School of Biomedical Sciences, Faculty of Medicine,The Chinese University of Hong Kong, 2Institute for Tissue Engineering and Regenerative Medicine,The Chinese University of Hong Kong, 3Center for Neuromusculoskeletal Restorative Medicine,The Chinese University of Hong Kong, 4Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences,The Chinese University of Hong Kong, 5Department of Orthopaedics and Traumatology, Faculty of Medicine,The Chinese University of Hong Kong
Summary
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This study details procedures for establishing a chronic-like rabbit rotator cuff (RC) injury. Specifically, the injury is created in the subscapularis (SSC) muscle-tendon/myotendinous unit to mimic human RC anatomy and pathophysiology, including severe muscle fatty degeneration (FD). This protocol can be applied to study RC injuries and assess regenerative therapies.
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Li, K., Zhang, X., Wang, D., Ker, D. F. E. Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration. J. Vis. Exp. (193), e64828, doi:10.3791/64828 (2023).
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